Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | HDAC3 | O15379 | 7/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 8/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.33 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.32 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.32 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.32 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.32 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.32 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.32 |
| ▸ | HDAC9 | Q9UKV0 | 3/20 | 0.32 |
| ▸ | HDAC5 | Q9UQL6 | 3/20 | 0.32 |
| ▸ | NAMPT | P43490 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12925030 | 0.94 | MAPT (0.40) | GAAMAPTHDAC3SMN1; SMN2 | |
| SCHEMBL12018901 | 0.93 | HDAC6 (0.34) | MAPTHDAC3SMN1; SMN2HDAC6HDAC1 | |
| SCHEMBL16503905 | 0.85 | LMNA (0.33) | MAPTHDAC3SMN1; SMN2HDAC6HDAC1 | |
| SCHEMBL4403236 | 0.85 | GSTP1 (0.45) | MAPTHDAC6 | |
| SCHEMBL4403233 | 0.84 | GSTP1 (0.41) | MAPTHDAC6 | |
| SCHEMBL14330482 | 0.84 | HDAC3 (0.33) | MAPTHDAC3SMN1; SMN2HDAC6HDAC1 | |
| SCHEMBL4437789 | 0.83 | HPGD (0.40) | MAPTHDAC3SMN1; SMN2HDAC6HDAC1 | |
| SCHEMBL12671652 | 0.83 | HDAC6 (0.33) | MAPTHDAC3SMN1; SMN2HDAC6HDAC1 | |
| SCHEMBL16153101 | 0.82 | HDAC6 (0.33) | MAPTHDAC3SMN1; SMN2HDAC6HDAC1 | |
| SCHEMBL15976894 | 0.82 | HDAC3 (0.33) | MAPTHDAC3SMN1; SMN2HDAC6HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120220013-A1 | COVALENT TETHERING OF FUNCTIONAL GROUPS TO PROTEINS AND SUBSTRATES THEREFOR | PROMEGA CORPORATION (US) | 2012-08-30 | — | — | US | disclosed |
| US-7425436-B2 | Covalent tethering of functional groups to proteins and substrates therefor | PROMEGA CORPORATION (US) | 2008-09-16 | — | — | US | disclosed |