Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 4/20 | 0.40 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | CASP7 | P55210 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17075211 | 0.81 | NOTUM (0.38) | NOTUMALOX15NPC1RAB9AKMT2A | |
| SCHEMBL11984354 | 0.77 | CACNA1G (0.43) | NOTUMCASP1CASP7NPC1RAB9A | |
| SCHEMBL16250257 | 0.75 | KDM4C (0.44) | NOTUMALDH1A1NPC1RAB9AOPRM1 | |
| SCHEMBL10029734 | 0.75 | TSHR (0.41) | KDM4ETSHR | |
| SCHEMBL30899464 | 0.75 | KDM4C (0.44) | NOTUMALDH1A1NPC1RAB9AOPRM1 | |
| SCHEMBL13180794 | 0.75 | NOTUM (0.45) | NOTUMALDH1A1ALOX15TSHR | |
| SCHEMBL28280937 | 0.72 | NOTUM (0.43) | NOTUMALDH1A1NPC1RAB9AKMT2A | |
| SCHEMBL28280809 | 0.72 | NOTUM (0.41) | NOTUMALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL11977476 | 0.71 | NOTUM (0.39) | NOTUMALDH1A1NPC1RAB9AKMT2A | |
| SCHEMBL19643771 | 0.70 | HTR6 (0.45) | NOTUMNPC1RAB9AKMT2AOPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2492262-A1 | FUSED HETEROCYCLIC COMPOUND AND THROMBOPOIETIN RECEPTOR ACTIVATOR | Nissan Chemical Industries, Ltd. (JP) | 2012-08-29 | — | — | EP | disclosed |