Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | CDC42 | P60953 | 3/20 | 0.40 |
| ▸ | RAC1 | P63000 | 3/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | RBP4 | P02753 | 1/20 | 0.36 |
| ▸ | HTR6 | P50406 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16250257 | 0.80 | KDM4C (0.44) | NOTUMALDH1A1CDC42RAC1PTGS1 | |
| SCHEMBL30899464 | 0.80 | KDM4C (0.44) | NOTUMALDH1A1CDC42RAC1PTGS1 | |
| SCHEMBL28280937 | 0.80 | NOTUM (0.43) | NOTUMALDH1A1CDC42RAC1PTGS1 | |
| SCHEMBL11984354 | 0.76 | CACNA1G (0.43) | NOTUMCDC42RAC1PTGS1PTGS2 | |
| SCHEMBL11977476 | 0.76 | NOTUM (0.39) | NOTUMALDH1A1CDC42RAC1PTGS1 | |
| SCHEMBL19643771 | 0.75 | HTR6 (0.45) | NOTUMCDC42RAC1PTGS1PTGS2 | |
| SCHEMBL8370418 | 0.73 | ALDH1A1 (0.48) | ALDH1A1CDC42RAC1PTGS1PTGS2 | |
| SCHEMBL17075211 | 0.72 | NOTUM (0.38) | NOTUMCDC42RAC1PTGS1PTGS2 | |
| SCHEMBL6070400 | 0.72 | HPGD (0.44) | ALDH1A1NPC1RAB9AKMT2ASMN1; SMN2 | |
| SCHEMBL12019284 | 0.72 | NOTUM (0.40) | NOTUMALDH1A1NPC1OPRM1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109475530-A | For treating the aminoacyl indazole immunomodulator of autoimmune disease | 洛克菲勒大学 | 2019-03-15 | — | — | CN | disclosed |