Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | HTR6 | P50406 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | CDC42 | P60953 | 3/20 | 0.35 |
| ▸ | RAC1 | P63000 | 3/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.34 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.34 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.34 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17075191 | 0.81 | NOTUM (0.35) | NOTUMKMT2ACNR2CHRM3LMNA | |
| SCHEMBL12019284 | 0.81 | NOTUM (0.40) | NOTUMKMT2AALOX15NPC1OPRM1 | |
| SCHEMBL17075198 | 0.79 | DPP4 (0.35) | NOTUMKMT2ACNR2LMNAHTT | |
| SCHEMBL28280937 | 0.75 | NOTUM (0.43) | NOTUMKMT2AHTR6CDC42RAC1 | |
| SCHEMBL30899464 | 0.75 | KDM4C (0.44) | NOTUMHTR6CNR2CDC42RAC1 | |
| SCHEMBL16250257 | 0.75 | KDM4C (0.44) | NOTUMHTR6CNR2CDC42RAC1 | |
| SCHEMBL15523890 | 0.72 | GPBAR1 (0.43) | OPRM1 | |
| SCHEMBL7353475 | 0.72 | CHRM2 (0.40) | KMT2ACHRM3 | |
| SCHEMBL28280809 | 0.72 | NOTUM (0.41) | NOTUMKMT2AHTR6CDC42RAC1 | |
| SCHEMBL11984354 | 0.71 | CACNA1G (0.43) | NOTUMKMT2ACDC42RAC1PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3116874-B1 | HEXAHYDRODIAZEPINOQUINOLINES CARRYING A SUBSTITUTED ALKYL RADICAL | ABBVIE DEUTSCHLAND (DE) | 2018-02-28 | — | — | EP | disclosed |
| US-20170112851-A1 | HEXAHYDRODIAZEPINOQUINOLINES CARRYING A SUBSTITUTED ALKYL RADICAL | AbbVie Deutschland GmbH & Co. KG (DE) | 2017-04-27 | — | — | US | disclosed |
| US-9540376-B2 | Hexahydrodiazepinoquinolines carrying a substituted alkyl radical | AbbVie Deutschland GmbH & Co. KG (DE) | 2017-01-10 | — | — | US | disclosed |
| US-20150259346-A1 | HEXAHYDRODIAZEPINOQUINOLINES CARRYING A SUBSTITUTED ALKYL RADICAL | AbbVie Deutschland GmbH & Co. KG (DE) | 2015-09-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170112851-A1 | HEXAHYDRODIAZEPINOQUINOLINES CARRYING A SUBSTITUTED ALKYL RADICAL | HTR2C, HTR2A, HTR3C | NOTUM 3126/4885KMT2A 1332/4885HTR6 18/4885 |
| US-20150259346-A1 | HEXAHYDRODIAZEPINOQUINOLINES CARRYING A SUBSTITUTED ALKYL RADICAL | HTR2C, HTR2A, HTR3C | NOTUM 3126/4885KMT2A 1332/4885HTR6 18/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.