Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR1 | P25024 | 6/20 | 0.44 |
| ▸ | CXCR2 | P25025 | 6/20 | 0.44 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | CNR1 | P21554 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.40 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.37 |
| ▸ | HTR1E | P28566 | 1/20 | 0.37 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.37 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.36 |
| ▸ | TCF7L2 | Q9NQB0 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | KIT | P10721 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1202454 | 0.84 | CXCR1 (0.52) | CXCR1CXCR2NR3C1KCNH2MAPK1 | |
| SCHEMBL2902263 | 0.83 | PPARA (0.39) | CXCR1CXCR2MAPTSMN1; SMN2 | |
| SCHEMBL1202165 | 0.77 | CXCR1 (0.52) | CXCR1CXCR2KCNH2MAPK1NPSR1 | |
| SCHEMBL1203816 | 0.77 | CXCR1 (0.52) | CXCR1CXCR2NR3C1KCNH2MAPK1 | |
| SCHEMBL1203737 | 0.76 | CTNNB1 (0.46) | CTNNB1TCF7L2ALDH1A1 | |
| SCHEMBL1204006 | 0.74 | CTNNB1 (0.41) | NPSR1MAPTCTNNB1TCF7L2ALDH1A1 | |
| SCHEMBL1203391 | 0.74 | ALDH1A1 (0.46) | CXCR1CXCR2MAPK1NPSR1MAPT | |
| SCHEMBL1202844 | 0.74 | CTNNB1 (0.47) | CXCR1CXCR2MAPK1NPSR1MAPT | |
| SCHEMBL1203791 | 0.74 | ALDH1A1 (0.46) | CXCR1CXCR2MAPK1NPSR1MAPT | |
| SCHEMBL1203100 | 0.73 | PIM1 (0.66) | CXCR1CXCR2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110046127-A1 | Imidazopyridazines for Use as Protein Kinase Inhibitors | CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS (CNIO) (ES) | 2011-02-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110046127-A1 | Imidazopyridazines for Use as Protein Kinase Inhibitors | PIM1, PIM3, PIM2 | CXCR1 2620/4885CXCR2 3383/4885NR3C1 2295/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.