SCHEMBL12041986

SCHEMBL12041986

Nc1nc(=O)n([C@H]2C[C@@H](O)[C@@H](CO)O2)cc1F

nearest known ligand 0.63

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
DNMT1 P26358 6/20 0.63
ADRB1 P08588 1/20 0.63
ALB P02768 1/20 0.61
LMNA P02545 3/20 0.60
SMN1; SMN2 Q16637 3/20 0.60
DNMT3B Q9UBC3 2/20 0.54
PNP P00491 1/20 0.49
TP53 P04637 1/20 0.49
HTT P42858 1/20 0.49
PDE4D Q08499 1/20 0.49
PDE3A Q14432 1/20 0.49
RXFP1 Q9HBX9 1/20 0.49
ALOX12 P18054 1/20 0.48
ADRA1A P35348 1/20 0.48
TK1 P04183 1/20 0.48
FPR2 P25090 1/20 0.48
POLG P54098 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5982928 1.00 DNMT1 (0.63) DNMT1ADRB1ALBLMNASMN1; SMN2
SCHEMBL207023 1.00 DNMT1 (0.63) DNMT1ADRB1ALBLMNASMN1; SMN2
SCHEMBL13262186 1.00 DNMT1 (0.63) DNMT1ADRB1ALBLMNASMN1; SMN2
SCHEMBL8345 1.00 DNMT1 (0.63) DNMT1ADRB1ALBLMNASMN1; SMN2
SCHEMBL16212282 1.00 DNMT1 (0.63) DNMT1ADRB1ALBLMNASMN1; SMN2
SCHEMBL5717505 1.00 DNMT1 (0.63) DNMT1ADRB1ALBLMNASMN1; SMN2
SCHEMBL24141674 1.00 DNMT1 (0.63) DNMT1ADRB1ALBLMNASMN1; SMN2
SCHEMBL7736439 1.00 DNMT1 (0.63) DNMT1ADRB1ALBLMNASMN1; SMN2
SCHEMBL5982921 1.00 DNMT1 (0.63) DNMT1ADRB1ALBLMNASMN1; SMN2
Phosphoric Acid SCHEMBL8409010 0.95 DNMT1 (0.58) DNMT1ADRB1ALBLMNASMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230285364-A1 USE OF A DHODH INHIBITOR COMPOUND IN COMBINATION CANCER THERAPY SERVIER PHARMACEUTICALS LLC 2023-09-14 US disclosed
US-20230241086-A1 ORAL FORMULATIONS OF CYTIDINE ANALOGS AND METHODS OF USE THEREOF CELGENE CORPORATION 2023-08-03 US disclosed
US-20180153916-A1 ISOTOPOLOGUES OF 5-AZACYTIDINE CELGENE CORPORATION 2018-06-07 US disclosed
US-9693987-B2 Methods for treating cancers using oral formulations of cytidine analogs CELGENE CORPORATION (US) 2017-07-04 US disclosed
US-9693987-B2 Methods for treating cancers using oral formulations of cytidine analogs CELGENE CORPORATION (US) 2017-07-04 US disclosed
US-20160250246-A1 ORAL FORMULATIONS OF CYTIDINE ANALOGS AND METHODS OF USE THEREOF CELGENE CORP (US) 2016-09-01 US disclosed
US-20160250246-A1 ORAL FORMULATIONS OF CYTIDINE ANALOGS AND METHODS OF USE THEREOF CELGENE CORP (US) 2016-09-01 US disclosed
US-20150374732-A1 ORAL FORMULATIONS OF CYTIDINE ANALOGS AND METHODS OF USE THEREOF CELGENE CORPORATION 2015-12-31 US disclosed
US-20150374732-A1 ORAL FORMULATIONS OF CYTIDINE ANALOGS AND METHODS OF USE THEREOF CELGENE CORPORATION 2015-12-31 US disclosed
US-20150290228-A1 ORAL FORMULATIONS OF CYTIDINE ANALOGS AND METHODS OF USE THEREOF CELGENE CORPORATION 2015-10-15 US disclosed
US-20150290228-A1 ORAL FORMULATIONS OF CYTIDINE ANALOGS AND METHODS OF USE THEREOF CELGENE CORPORATION 2015-10-15 US disclosed
US-20150216886-A1 METHODS FOR TREATING CANCERS USING ORAL FORMULATIONS OF CYTIDINE ANALOGS CELGENE CORP (US) 2015-08-06 US disclosed
US-20150056280-A1 ISOTOPOLOGUES OF 5-AZACYTIDINE CELGENE CORPORATION 2015-02-26 US disclosed
US-8846628-B2 Oral formulations of cytidine analogs and methods of use thereof CELGENE CORPORATION (US) 2014-09-30 US disclosed
US-8492361-B2 Methods for treating non-small cell lung cancer using 5-azacytidine CELGENE CORPORATION (US) 2013-07-23 US disclosed
US-8492361-B2 Methods for treating non-small cell lung cancer using 5-azacytidine CELGENE CORPORATION (US) 2013-07-23 US disclosed
US-20130085115-A1 COMBINATION THERAPY FOR LYMPHOMA CELGENE CORPORATION (US) 2013-04-04 US disclosed
US-20110319355-A1 METHODS FOR TREATING NON-SMALL CELL LUNG CANCER USING 5-AZACYTIDINE PHARMION LLC 2011-12-29 US disclosed
US-20090286752-A1 ORAL FORMULATIONS OF CYTIDINE ANALOGS AND METHODS OF USE THEREOF CELGENE CORPORATION 2009-11-19 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (11 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230285364-A1 USE OF A DHODH INHIBITOR COMPOUND IN COMBINATION CANCER THERAPY DHODH, DPYD, DLD DNMT1 2226/4885ADRB1 2988/4885ALB 4480/4885
US-20150216886-A1 METHODS FOR TREATING CANCERS USING ORAL FORMULATIONS OF CYTIDINE ANALOGS CDA, DCTD, DCK DNMT1 102/4885ADRB1 4626/4885ALB 2377/4885
US-20150056280-A1 ISOTOPOLOGUES OF 5-AZACYTIDINE UNG, DCTD, DPYD DNMT1 13/4885ADRB1 3825/4885ALB 3212/4885
US-20150374732-A1 ORAL FORMULATIONS OF CYTIDINE ANALOGS AND METHODS OF USE THEREOF DCTD, CDA, NT5C2 DNMT1 403/4885ADRB1 3992/4885ALB 3033/4885
US-20230241086-A1 ORAL FORMULATIONS OF CYTIDINE ANALOGS AND METHODS OF USE THEREOF DCTD, CDA, NT5C2 DNMT1 403/4885ADRB1 3992/4885ALB 3033/4885
US-20090286752-A1 ORAL FORMULATIONS OF CYTIDINE ANALOGS AND METHODS OF USE THEREOF DCTD, CDA, NT5C2 DNMT1 403/4885ADRB1 3992/4885ALB 3033/4885
US-20130085115-A1 COMBINATION THERAPY FOR LYMPHOMA BCL6, MALT1, HDAC5 DNMT1 15/4885ADRB1 4830/4885ALB 4642/4885
US-20180153916-A1 ISOTOPOLOGUES OF 5-AZACYTIDINE UNG, DCTD, DPYD DNMT1 13/4885ADRB1 3825/4885ALB 3212/4885
US-20110319355-A1 METHODS FOR TREATING NON-SMALL CELL LUNG CANCER USING 5-AZACYTIDINE DCTD, NSUN2, RNMT DNMT1 15/4885ADRB1 4626/4885ALB 4844/4885
US-20160250246-A1 ORAL FORMULATIONS OF CYTIDINE ANALOGS AND METHODS OF USE THEREOF BCL6, BCL3, BCL9 DNMT1 59/4885ADRB1 4580/4885ALB 1266/4885
US-20150290228-A1 ORAL FORMULATIONS OF CYTIDINE ANALOGS AND METHODS OF USE THEREOF BCL6, BCL3, BCL9 DNMT1 59/4885ADRB1 4580/4885ALB 1266/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.