Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 13/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 11/20 | 0.47 |
| ▸ | MAPT | P10636 | 7/20 | 0.44 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.44 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.44 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 5/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 7/20 | 0.40 |
| ▸ | HPGD | P15428 | 6/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | GFER | P55789 | 1/20 | 0.39 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27921919 | 0.81 | ALDH1A1 (0.42) | ALDH1A1KDM4EMAPTCHEK1LIMK1 | |
| SCHEMBL16473318 | 0.80 | KDM4E (0.53) | ALDH1A1KDM4EMAPTCHEK1LIMK1 | |
| SCHEMBL20455586 | 0.78 | KDM4E (0.47) | ALDH1A1KDM4EMAPTCHEK1LIMK1 | |
| SCHEMBL31447720 | 0.74 | ALDH1A1 (0.49) | ALDH1A1KDM4EMAPTCHEK1LIMK1 | |
| SCHEMBL4327194 | 0.74 | MAPK1 (0.51) | ALDH1A1KDM4EMAPTCHEK1LIMK1 | |
| SCHEMBL16569164 | 0.74 | ALDH1A1 (0.53) | ALDH1A1KDM4EMAPTCHEK1LIMK1 | |
| SCHEMBL18152008 | 0.71 | ALDH1A1 (0.47) | ALDH1A1KDM4EMAPTCHEK1LIMK1 | |
| SCHEMBL13159751 | 0.71 | NPC1 (0.58) | ALDH1A1KDM4EMAPTRAB9AHPGD | |
| SCHEMBL15094046 | 0.71 | RAB9A (0.42) | ALDH1A1KDM4EMAPTCHEK1LIMK1 | |
| SCHEMBL18086799 | 0.71 | ALDH1A1 (0.44) | ALDH1A1KDM4EMAPTCHEK1LIMK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7893280-B2 | 2,4-disubstituted thiazolyl derivatives | JANSSEN PHARMACEUTICA NV (BE) | 2011-02-22 | — | — | US | disclosed |
| EP-1261607-B1 | 2,4-DISUBSTITUTED THIAZOLYL DERIVATIVES | JANSSEN PHARMACEUTICA NV (BE) | 2008-11-12 | — | — | EP | disclosed |
| US-20060211704-A1 | 2,4-Disubstituted thiazolyl derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-09-21 | — | — | US | disclosed |
| US-7105550-B2 | 2,4-disubstituted thiazolyl derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-09-12 | — | — | US | disclosed |
| US-20030203897-A1 | 2,4-Disubstituted thiazolyl derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 2003-10-30 | — | — | US | disclosed |
| EP-1261607-A1 | 2,4-DISUBSTITUTED THIAZOLYL DERIVATIVES | Janssen Pharmaceutica N.V. (BE) | 2002-12-04 | — | — | EP | disclosed |
| WO-2001064674-A1 | 2,4-DISUBSTITUTED THIAZOLYL DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 2001-09-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060211704-A1 | 2,4-Disubstituted thiazolyl derivatives | IL4, PTGER4, PTGER3 | ALDH1A1 1775/4885KDM4E 2474/4885MAPT 4808/4885 |
| US-20030203897-A1 | 2,4-Disubstituted thiazolyl derivatives | IL4, PTGER4, PTGER1 | ALDH1A1 1094/4885KDM4E 2524/4885MAPT 4839/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.