Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.34 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | CASP3 | P42574 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.34 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.34 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.34 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 2/20 | 0.33 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17433153 | 0.86 | NPC1 (0.39) | NPC1RAB9AMAPTMAPK1SMN1; SMN2 | |
| SCHEMBL20932948 | 0.86 | CNR2 (0.36) | NR1H2NR1H3ALOX5APPDE10ACNR2 | |
| SCHEMBL13751317 | 0.85 | NPC1 (0.38) | NPC1RAB9AMAPTMAPK1SMN1; SMN2 | |
| SCHEMBL19388193 | 0.81 | TRPV4 (0.47) | NPC1RAB9AMAPTNR1H2NR1H3 | |
| SCHEMBL2733258 | 0.80 | LMNA (0.39) | NPC1RAB9AMAPTSMN1; SMN2LMNA | |
| SCHEMBL24397795 | 0.77 | KMT2A (0.46) | RAB9AMAPTNR1H2NR1H3SMN1; SMN2 | |
| SCHEMBL18745377 | 0.77 | NPC1 (0.38) | NPC1RAB9AMAPTMAPK1SMN1; SMN2 | |
| SCHEMBL15499726 | 0.77 | LOXL2 (0.36) | NPC1RAB9AMAPTMAPK1SMN1; SMN2 | |
| SCHEMBL12295857 | 0.75 | NPC1 (0.39) | NPC1RAB9AMAPTMAPK1SMN1; SMN2 | |
| SCHEMBL18869960 | 0.74 | HPGD (0.42) | NPC1RAB9ANR1H2NR1H3MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110301145-A1 | PYRIDAZINONES, METHOD OF MAKING, AND METHOD OF USE THEREOF | Gilead Connecticut INc. (US) | 2011-12-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110301145-A1 | PYRIDAZINONES, METHOD OF MAKING, AND METHOD OF USE THEREOF | BTK, SYK, LCK | NPC1 3233/4885RAB9A 3665/4885MAPT 4467/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.