Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPAR1 | Q92633 | 7/20 | 0.45 |
| ▸ | LPAR3 | Q9UBY5 | 7/20 | 0.45 |
| ▸ | LPAR2 | Q9HBW0 | 4/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | TLR2 | O60603 | 4/20 | 0.37 |
| ▸ | LPAR6 | P43657 | 3/20 | 0.36 |
| ▸ | LPAR4 | Q99677 | 3/20 | 0.36 |
| ▸ | LPAR5 | Q9H1C0 | 3/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | CNR1 | P21554 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12301807 | 1.00 | LPAR1 (0.45) | LPAR1LPAR3LPAR2TSHRUSP2 | |
| SCHEMBL12047460 | 1.00 | LPAR1 (0.45) | LPAR1LPAR3LPAR2TSHRUSP2 | |
| SCHEMBL12047466 | 0.97 | LPAR1 (0.47) | LPAR1LPAR3LPAR2TSHRUSP2 | |
| SCHEMBL12047468 | 0.97 | LPAR1 (0.47) | LPAR1LPAR3LPAR2TSHRUSP2 | |
| SCHEMBL12047457 | 0.93 | TSHR (0.43) | LPAR1LPAR3LPAR2TSHRUSP2 | |
| SCHEMBL12047469 | 0.91 | LPAR1 (0.51) | LPAR1LPAR3LPAR2TSHRUSP2 | |
| SCHEMBL10028014 | 0.91 | LPAR1 (0.51) | LPAR1LPAR3LPAR2TSHRUSP2 | |
| SCHEMBL12301810 | 0.89 | HSD17B10 (0.46) | LPAR1LPAR3LPAR2TSHRUSP2 | |
| SCHEMBL12301812 | 0.88 | TDP1 (0.42) | LPAR1LPAR3LPAR2TSHRUSP2 | |
| SCHEMBL12047461 | 0.88 | LPAR1 (0.42) | LPAR1LPAR3LPAR2TSHRUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8741283-B2 | Adenosine deaminase anticancer therapy | SIGMA-TAU RARE DISEASES, S.A. (PT) | 2014-06-03 | — | — | US | disclosed |
| US-8071741-B2 | Stable recombinant adenosine deaminase | DEFIANTE FARMACEUTICA, S.A. (PT) | 2011-12-06 | — | — | US | disclosed |