Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPAR1 | Q92633 | 7/20 | 0.51 |
| ▸ | LPAR3 | Q9UBY5 | 7/20 | 0.51 |
| ▸ | LPAR2 | Q9HBW0 | 4/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | TLR2 | O60603 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | LPAR6 | P43657 | 3/20 | 0.41 |
| ▸ | LPAR4 | Q99677 | 3/20 | 0.41 |
| ▸ | LPAR5 | Q9H1C0 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | DNM1 | Q05193 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10028014 | 1.00 | LPAR1 (0.51) | LPAR1LPAR3LPAR2TSHRUSP2 | |
| SCHEMBL12047466 | 0.94 | LPAR1 (0.47) | LPAR1LPAR3LPAR2TSHRUSP2 | |
| SCHEMBL12047468 | 0.94 | LPAR1 (0.47) | LPAR1LPAR3LPAR2TSHRUSP2 | |
| SCHEMBL12047460 | 0.91 | LPAR1 (0.45) | LPAR1LPAR3LPAR2TSHRUSP2 | |
| SCHEMBL14616861 | 0.91 | HSD17B10 (0.50) | LPAR1LPAR3LPAR2TSHRUSP2 | |
| SCHEMBL12047464 | 0.91 | LPAR1 (0.45) | LPAR1LPAR3LPAR2TSHRUSP2 | |
| SCHEMBL12301807 | 0.91 | LPAR1 (0.45) | LPAR1LPAR3LPAR2TSHRUSP2 | |
| SCHEMBL11314764 | 0.90 | LPAR1 (0.63) | LPAR1LPAR3LPAR2USP2TLR2 | |
| SCHEMBL12047457 | 0.90 | TSHR (0.43) | LPAR1LPAR3LPAR2TSHRUSP2 | |
| SCHEMBL8953351 | 0.89 | LPAR1 (0.46) | LPAR1LPAR3LPAR2TSHRUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8741283-B2 | Adenosine deaminase anticancer therapy | SIGMA-TAU RARE DISEASES, S.A. (PT) | 2014-06-03 | — | — | US | disclosed |
| US-8367065-B2 | Targeted polymeric prodrugs containing multifunctional linkers | ENZON PHARMACEUTICALS, INC. (US) | 2013-02-05 | — | — | US | disclosed |
| US-8268318-B2 | Polyalkylene oxides having hindered ester-based biodegradable linkers | ENZON PHARMACEUTICALS, INC. (US) | 2012-09-18 | — | — | US | disclosed |
| US-8071741-B2 | Stable recombinant adenosine deaminase | DEFIANTE FARMACEUTICA, S.A. (PT) | 2011-12-06 | — | — | US | disclosed |
| US-20100273236-A1 | RECOMBINANT HOST FOR PRODUCING L-ASPARAGINASE II | DEFIANTE FARMACEUTICA, S.A. (PT) | 2010-10-28 | — | — | US | disclosed |
| US-7807436-B2 | genetic engineered escherichia comprising chromosome and genetic vectors, that code for hydrolase enzymes; drug/polymer conjugates/ used for treatment of diseases or disorders responsive to asparaginases | DEFIANTE FARMACEUTICA, S.A. (PT) | 2010-10-05 | — | — | US | disclosed |
| US-20100233190-A1 | TARGETED POLYMERIC PRODRUGS CONTAINING MULTIFUNCTIONAL LINKERS | ENZON PHARMACEUTICALS, INC. (US) | 2010-09-16 | — | — | US | disclosed |
| US-20100203066-A1 | POLYMERIC LINKERS CONTAINING PYRIDYL DISULFIDE MOIETIES | ENZON PHARMACEUTICALS, INC. (US) | 2010-08-12 | — | — | US | disclosed |
| US-20100056543-A1 | POSACONAZOLE POLYMER CONJUGATES AND METHODS OF TREATMENT USING POSACONAZOLE AND POLYMER CONJUGATES THEREOF | ENZON PHARMACEUTICALS, INC. (US) | 2010-03-04 | — | — | US | disclosed |
| US-20090232833-A1 | POLYALKYLENE OXIDES HAVING HINDERED ESTER-BASED BIODEGRADABLE LINKERS | ENZON PHARMACEUTICALS, INC. (US) | 2009-09-17 | — | — | US | disclosed |
| US-20090047270-A1 | ENZYMATIC ANTICANCER THERAPY | ENZON PHARMACEUTICALS, INC. (US) | 2009-02-19 | — | — | US | disclosed |
| US-20090047271-A1 | STABLE RECOMBINANT ADENOSINE DEAMINASE | ENZON PHARMACEUTICALS, INC. (US) | 2009-02-19 | — | — | US | disclosed |
| US-20090017004-A1 | POLYMERIC DRUG DELIVERY SYSTEMS CONTAINING AN AROMATIC ALLYLIC ACID | ENZON PHARMACEUTICALS, INC. (US) | 2009-01-15 | — | — | US | disclosed |
| US-20090016985-A1 | POLYMERIC DRUG DELIVERY SYSTEM CONTAINING A MULTI-SUBSTITUTED AROMATIC MOIETY | ENZON PHARMACEUTICALS, INC. (US) | 2009-01-15 | — | — | US | disclosed |
| US-20080171013-A1 | POSACONAZOLE POLYMER CONJUGATES AND METHODS OF TREATMENT USING POSACONAZOLE AND POLYMER CONJUGATES THEREOF | ENZON PHARMACEUTICALS, INC. (US) | 2008-07-17 | — | — | US | disclosed |
| US-20080159964-A1 | USE OF ADENOSINE DEAMINASE FOR TREATING PULMONARY DISEASE | ENZON PHARMACEUTICALS, INC. (US) | 2008-07-03 | — | — | US | disclosed |
| US-20080063632-A1 | RECOMBINANT HOST FOR PRODUCING L-ASPARAGINASE II | SIGMA-TAU PHARMA LIMITED (GB) | 2008-03-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (11 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100233190-A1 | TARGETED POLYMERIC PRODRUGS CONTAINING MULTIFUNCTIONAL LINKERS | PAICS, FCGRT, DNPEP | LPAR1 1052/4885LPAR3 963/4885LPAR2 763/4885 |
| US-20090047270-A1 | ENZYMATIC ANTICANCER THERAPY | RNASE1, ADA, DCTD | LPAR1 3234/4885LPAR3 3409/4885LPAR2 3064/4885 |
| US-20080159964-A1 | USE OF ADENOSINE DEAMINASE FOR TREATING PULMONARY DISEASE | ADA, AMPD2, AMPD1 | LPAR1 1423/4885LPAR3 1286/4885LPAR2 1455/4885 |
| US-20090017004-A1 | POLYMERIC DRUG DELIVERY SYSTEMS CONTAINING AN AROMATIC ALLYLIC ACID | AADAC, ACSS2, ANXA6 | LPAR1 211/4885LPAR3 177/4885LPAR2 148/4885 |
| US-20090016985-A1 | POLYMERIC DRUG DELIVERY SYSTEM CONTAINING A MULTI-SUBSTITUTED AROMATIC MOIETY | ABCB1, PAICS, ABCG2 | LPAR1 1228/4885LPAR3 572/4885LPAR2 1071/4885 |
| US-20090232833-A1 | POLYALKYLENE OXIDES HAVING HINDERED ESTER-BASED BIODEGRADABLE LINKERS | CES2, PLOD3, FASN | LPAR1 898/4885LPAR3 1016/4885LPAR2 823/4885 |
| US-20080063632-A1 | RECOMBINANT HOST FOR PRODUCING L-ASPARAGINASE II | ENGASE, LAP3, LNPEP | LPAR1 3130/4885LPAR3 3151/4885LPAR2 2867/4885 |
| US-20080171013-A1 | POSACONAZOLE POLYMER CONJUGATES AND METHODS OF TREATMENT USING POSACONAZOLE AND POLYMER CONJUGATES THEREOF | ALG1, DDOST, B3GAT3 | LPAR1 3622/4885LPAR3 2051/4885LPAR2 3823/4885 |
| US-20100056543-A1 | POSACONAZOLE POLYMER CONJUGATES AND METHODS OF TREATMENT USING POSACONAZOLE AND POLYMER CONJUGATES THEREOF | ALG1, DDOST, B3GAT3 | LPAR1 3622/4885LPAR3 2051/4885LPAR2 3823/4885 |
| US-20090047271-A1 | STABLE RECOMBINANT ADENOSINE DEAMINASE | ADA, CDA, DCTD | LPAR1 4227/4885LPAR3 4305/4885LPAR2 4389/4885 |
| US-20100203066-A1 | POLYMERIC LINKERS CONTAINING PYRIDYL DISULFIDE MOIETIES | P4HB, PRDX4, SCLY | LPAR1 2514/4885LPAR3 1286/4885LPAR2 2255/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.