Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.71 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.70 |
| ▸ | ATM | Q13315 | 2/20 | 0.64 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.62 |
| ▸ | GAA | P10253 | 2/20 | 0.60 |
| ▸ | HTT | P42858 | 2/20 | 0.60 |
| ▸ | POLB | P06746 | 1/20 | 0.60 |
| ▸ | LMNA | P02545 | 1/20 | 0.60 |
| ▸ | TSHR | P16473 | 1/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.60 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.60 |
| ▸ | MEN1 | O00255 | 2/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5345711 | 0.89 | ALDH1A1 (0.68) | ALDH1A1PRMT1ATMMCL1GAA | |
| SCHEMBL9305676 | 0.85 | PRMT1 (0.74) | ALDH1A1PRMT1ATMMCL1GAA | |
| SCHEMBL29530578 | 0.85 | PRMT1 (0.74) | ALDH1A1PRMT1ATMMCL1GAA | |
| SCHEMBL1873887 | 0.85 | PRMT1 (0.77) | ALDH1A1PRMT1ATMMCL1GAA | |
| SCHEMBL1169648 | 0.83 | ALDH1A1 (1.00) | ALDH1A1PRMT1ATMMCL1GAA | |
| SCHEMBL15826010 | 0.82 | PRMT1 (0.74) | ALDH1A1PRMT1ATMMCL1GAA | |
| SCHEMBL1169464 | 0.82 | PRMT1 (0.74) | ALDH1A1PRMT1ATMMCL1GAA | |
| SCHEMBL15822958 | 0.82 | PRMT1 (1.00) | ALDH1A1PRMT1ATMMCL1GAA | |
| SCHEMBL3925507 | 0.82 | PRMT1 (0.74) | ALDH1A1PRMT1ATMMCL1GAA | |
| SCHEMBL29530569 | 0.82 | PRMT1 (0.74) | ALDH1A1PRMT1ATMMCL1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8357699-B2 | 6-aminoisoquinoline compounds | AERIE PHARMACEUTICALS, INC. (US) | 2013-01-22 | — | — | US | disclosed |
| US-20110319390-A1 | 6-Aminoisoquinoline Compounds | AERIE PHARMACEUTICALS, INC. (US) | 2011-12-29 | — | — | US | disclosed |
| US-8034943-B2 | 6-aminoisoquinoline compounds | AERIE PHARMACEUTICALS, INC. (US) | 2011-10-11 | — | — | US | disclosed |
| US-20110183965-A1 | 6-AMINOISOQUINOLINE COMPOUNDS | AERIE PHARMACEUTICALS, INC. (US) | 2011-07-28 | — | — | US | disclosed |
| US-20100137364-A1 | 6-Aminoisoquinoline Compounds | AERIE PHARMACEUTICALS, INC. (US) | 2010-06-03 | — | — | US | disclosed |
| US-7671205-B2 | 6-aminoisoquinoline compounds | AERIE PHARMACEUTICALS, INC. (US) | 2010-03-02 | — | — | US | disclosed |
| US-20080167340-A1 | 6-Aminoisoquinoline Compounds | AERIE PHARMACEUTICALS, INC. (US) | 2008-07-10 | — | — | US | disclosed |
| US-20070173530-A1 | 6-Aminoisoquinoline Compounds | AERIE PHARMACEUTICALS, INC. (US) | 2007-07-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100137364-A1 | 6-Aminoisoquinoline Compounds | COQ8A, PGC, AGK | ALDH1A1 2478/4885PRMT1 1383/4885ATM 183/4885 |
| US-20080167340-A1 | 6-Aminoisoquinoline Compounds | COQ8A, PGC, AGK | ALDH1A1 2478/4885PRMT1 1383/4885ATM 183/4885 |
| US-20070173530-A1 | 6-Aminoisoquinoline Compounds | COQ8A, PGC, AGK | ALDH1A1 2478/4885PRMT1 1383/4885ATM 183/4885 |
| US-20110183965-A1 | 6-AMINOISOQUINOLINE COMPOUNDS | COQ8A, PGC, AGK | ALDH1A1 2478/4885PRMT1 1383/4885ATM 183/4885 |
| US-20110319390-A1 | 6-Aminoisoquinoline Compounds | COQ8A, PGC, AGK | ALDH1A1 2478/4885PRMT1 1383/4885ATM 183/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.