Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 6/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 6/20 | 0.46 |
| ▸ | HTR3A | P46098 | 2/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.46 |
| ▸ | TRPM5 | Q9NZQ8 | 2/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.43 |
| ▸ | PARP15 | Q460N3 | 3/20 | 0.42 |
| ▸ | PARP10 | Q53GL7 | 3/20 | 0.42 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.39 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.39 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.39 |
| ▸ | CDK1 | P06493 | 1/20 | 0.38 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8965547 | 0.78 | KMT2A (0.50) | TRPM5TRPA1 | |
| SCHEMBL8966123 | 0.74 | CA12 (0.49) | TRPM5TRPA1 | |
| SCHEMBL16902875 | 0.72 | SLC6A2 (0.78) | SLC6A2SLC6A4HTR3AKCNH2SLC6A3 | |
| SCHEMBL20024437 | 0.72 | SLC6A2 (0.78) | SLC6A2SLC6A4HTR3AKCNH2SLC6A3 | |
| SCHEMBL29024848 | 0.70 | PARP15 (0.64) | PARP15PARP10PARP2 | |
| SCHEMBL12338079 | 0.70 | TRPM5 (0.54) | SLC6A2SLC6A4TRPM5SLC6A3TRPA1 | |
| SCHEMBL2488995 | 0.70 | EGFR (0.58) | SLC6A2SLC6A4HTR3AKCNH2SLC6A3 | |
| SCHEMBL9112701 | 0.70 | TRPA1 (0.49) | SLC6A2SLC6A4HTR3AKCNH2SLC6A3 | |
| SCHEMBL8476825 | 0.69 | SLC6A2 (0.55) | SLC6A2SLC6A4HTR3AKCNH2SLC6A3 | |
| SCHEMBL31094204 | 0.68 | SLC6A2 (0.54) | SLC6A2SLC6A4HTR3AKCNH2SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8263619-B2 | Indazoles, benzothiazoles, benzoisothiazoles, benzisoxazoles, and preparation and uses thereof | MEMORY PHARMACEUTICALS CORPORATION (US) | 2012-09-11 | — | — | US | disclosed |
| US-20110319407-A1 | INDAZOLES, BENZOTHIAZOLES, BENZOISOTHIAZOLES, BENZISOXAZOLES, AND PREPARATION AND USE THEREOF | XIE WENGE (US) | 2011-12-29 | — | — | US | disclosed |
| US-20100105677-A1 | INDAZOLES, BENZOTHIAZOLES, BENZOISOTHIAZOLES, BENZISOXAZOLES, AND PREPARATION AND USES THEREOF | XIE WENGE | 2010-04-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110319407-A1 | INDAZOLES, BENZOTHIAZOLES, BENZOISOTHIAZOLES, BENZISOXAZOLES, AND PREPARATION AND USE THEREOF | CHRNA7, CHRNA5, CHRNA3 | SLC6A2 953/4885SLC6A4 1440/4885HTR3A 352/4885 |
| US-20100105677-A1 | INDAZOLES, BENZOTHIAZOLES, BENZOISOTHIAZOLES, BENZISOXAZOLES, AND PREPARATION AND USES THEREOF | CHRNA7, CHRNA5, CHRNA3 | SLC6A2 950/4885SLC6A4 1422/4885HTR3A 367/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.