Sugi Predict

Sugi Predict / Compounds / SCHEMBL12060293

SCHEMBL12060293

SCHEMBL12060293

COc1ccc(N=O)c(Cl)n1

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ POLB P06746 1/20 0.37
▸ TDP1 Q9NUW8 1/20 0.37
▸ NNMT P40261 2/20 0.36
▸ HTT P42858 3/20 0.34
▸ ALDH1A1 P00352 2/20 0.34
▸ RAB9A P51151 2/20 0.34
▸ MAPT P10636 2/20 0.34
▸ MAPK1 P28482 2/20 0.34
▸ NPC1 O15118 1/20 0.34
▸ JAK2 O60674 1/20 0.34
▸ S1PR4 O95977 1/20 0.34
▸ HSP90AA1 P07900 1/20 0.34
▸ S1PR1 P21453 1/20 0.34
▸ NPSR1 Q6W5P4 1/20 0.34
▸ TXNRD1 Q16881 5/20 0.33
▸ GSR P00390 1/20 0.33
▸ HPGD P15428 2/20 0.33
▸ TSHR P16473 2/20 0.33
▸ SMN1; SMN2 Q16637 2/20 0.33
▸ HSD17B10 Q99714 2/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2608531 0.78 NNMT (0.49) POLBTDP1NNMTKMT2ASIRT2
SCHEMBL23620229 0.78 POLB (0.38) POLBTDP1NNMTALDH1A1MAPT
SCHEMBL21620863 0.77 POLB (0.37) POLBTDP1NNMTALDH1A1MAPT
SCHEMBL13233495 0.77 NNMT (0.40) POLBTDP1NNMTALDH1A1RAB9A
SCHEMBL12516223 0.74 — —
SCHEMBL12828301 0.74 CCR1 (0.36) POLBHTTALDH1A1RAB9AMAPT
SCHEMBL15228338 0.73 ALDH1A1 (0.45) POLBTDP1NNMTALDH1A1MAPT
SCHEMBL10071721 0.73 CYP3A4 (0.32) TSHR
SCHEMBL29581181 0.73 HPGD (0.40) POLBTDP1NNMTHTTALDH1A1
SCHEMBL911440 0.73 HPGD (0.40) POLBTDP1NNMTHTTALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3661936-B1 [1,2,4]TRIAZOLO[4,3-A]PYRAZIN-6(5H)-ONE DERIVATIVES LILLY CO ELI (US) 2021-12-22 — — EP disclosed
US-8071592-B2 Derivatives and analogs of N-ethylquinolones and N-ethylazaquinolones GLAXO GROUP LIMITED (GB) 2011-12-06 — — US disclosed
US-20100098634-A1 Imaging Agents Useful for Identifying AD Pathology SIEMENS MEDICAL SOLUTIONS USA, INC. 2010-04-22 — — US disclosed
US-7687639-B2 Substituted benzimidazoles and imidazo-[4,5]-pyridines JANSSEN PHARMACEUTICA N.V. (BE) 2010-03-30 — — US disclosed
US-20090270374-A1 DERIVATIVES AND ANALOGS OF N-ETHYLQUINOLONES AND N-ETHYLAZAQUINOLONES GLAXO GROUP LIMITED (GB) 2009-10-29 — — US disclosed
US-20090143361-A1 Pyrido[3,2-E]Pyrazines, Process For Preparing The Same, And Their Use As Inhibitors Of Phosphodiesterase 10 ELBION GMBH (DE) 2009-06-04 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090143361-A1 Pyrido[3,2-E]Pyrazines, Process For Preparing The Same, And Their Use As Inhibitors Of Phosphodiesterase 10 PDE12, PDE5A, PDE3A POLB 1544/4885TDP1 185/4885NNMT 665/4885
US-20100098634-A1 Imaging Agents Useful for Identifying AD Pathology APP, APBA1, PYGB POLB 2509/4885TDP1 129/4885NNMT 2170/4885
US-20090270374-A1 DERIVATIVES AND ANALOGS OF N-ETHYLQUINOLONES AND N-ETHYLAZAQUINOLONES ETFA, NQO2, GNAQ POLB 293/4885TDP1 2119/4885NNMT 97/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.