Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHUK | O15111 | 3/20 | 0.40 |
| ▸ | INSR | P06213 | 3/20 | 0.40 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.40 |
| ▸ | CAMKK2 | Q96RR4 | 3/20 | 0.40 |
| ▸ | RIPK1 | Q13546 | 3/20 | 0.36 |
| ▸ | F10 | P00742 | 4/20 | 0.34 |
| ▸ | CSF1R | P07333 | 1/20 | 0.33 |
| ▸ | F9 | P00740 | 1/20 | 0.33 |
| ▸ | AKT1 | P31749 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | SPR | P35270 | 1/20 | 0.32 |
| ▸ | ERBB2 | P04626 | 4/20 | 0.32 |
| ▸ | KDR | P35968 | 4/20 | 0.32 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.32 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.32 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.32 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.32 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.32 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14049 | 0.86 | KIT (0.34) | ERBB2KDRHDAC3HDAC4HDAC1 | |
| SCHEMBL14232 | 0.80 | RIPK1 (0.39) | CHUKINSRMAPK8CAMKK2RIPK1 | |
| SCHEMBL17484562 | 0.80 | LMNA (0.38) | CHUKINSRMAPK8CAMKK2F10 | |
| SCHEMBL13627 | 0.79 | F9 (0.38) | CHUKINSRMAPK8CAMKK2F10 | |
| SCHEMBL14438 | 0.78 | EGFR (0.37) | RIPK1CSF1RERBB2KDRHDAC3 | |
| SCHEMBL14568 | 0.78 | F10 (0.41) | CHUKINSRMAPK8CAMKK2RIPK1 | |
| SCHEMBL21367988 | 0.78 | CHUK (0.34) | CHUKINSRMAPK8CAMKK2 | |
| SCHEMBL12075213 | 0.78 | MEN1 (0.39) | CHUKINSRMAPK8CAMKK2F10 | |
| SCHEMBL14447 | 0.77 | KIT (0.36) | CSF1RERBB2KDRHDAC3HDAC4 | |
| SCHEMBL14030 | 0.77 | P2RY14 (0.39) | CHUKINSRMAPK8CAMKK2F10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9193731-B2 | Antimicrobial compounds and methods of making and using the same | MELINTA THERAPEUTICS, INC. (US) | 2015-11-24 | — | — | US | disclosed |
| US-9193731-B2 | Antimicrobial compounds and methods of making and using the same | MELINTA THERAPEUTICS, INC. (US) | 2015-11-24 | — | — | US | disclosed |
| US-20120220566-A1 | Antimicrobial Compounds and Methods of Making and Using the Same | RIB-X PHARMACEUTICALS, INC. (US) | 2012-08-30 | — | — | US | disclosed |
| US-20120220566-A1 | Antimicrobial Compounds and Methods of Making and Using the Same | RIB-X PHARMACEUTICALS, INC. (US) | 2012-08-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120220566-A1 | Antimicrobial Compounds and Methods of Making and Using the Same | MPO, LPO, CAT | CHUK 2953/4885INSR 4144/4885MAPK8 4287/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.