Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2C | P18825 | 3/20 | 0.50 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.50 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.50 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.50 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | APEX1 | P27695 | 1/20 | 0.48 |
| ▸ | RAD52 | P43351 | 1/20 | 0.48 |
| ▸ | RECQL | P46063 | 1/20 | 0.48 |
| ▸ | BLM | P54132 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.47 |
| ▸ | CES2 | O00748 | 1/20 | 0.46 |
| ▸ | CES1 | P23141 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30288482 | 1.00 | ADRA2C (0.50) | ADRA2CADRA1AADRB2ADRA2AADRA2B | |
| SCHEMBL7150641 | 1.00 | ADRA2C (0.50) | ADRA2CADRA1AADRB2ADRA2AADRA2B | |
| Hydrochloric Acid SCHEMBL2323838 | 0.98 | KDM4E (0.52) | ADRA2CADRA1AADRB2ADRA2AADRA2B | |
| SCHEMBL16371920 | 0.87 | CES2 (0.43) | ADRA2CADRA1AADRB2ADRA2AADRA2B | |
| SCHEMBL1444988 | 0.83 | IDO1 (0.48) | ADRA2CADRA1AADRB2ADRA2AADRA2B | |
| SCHEMBL7153251 | 0.83 | ADRA2C (0.53) | ADRA2CADRA1AADRB2ADRA2AADRA2B | |
| SCHEMBL25159719 | 0.82 | CES2 (0.46) | CYP3A4CES2CES1IDO1TDO2 | |
| SCHEMBL15078367 | 0.82 | CES2 (0.46) | CYP3A4CES2CES1IDO1TDO2 | |
| SCHEMBL23489941 | 0.82 | CES2 (0.46) | CYP3A4CES2CES1IDO1TDO2 | |
| SCHEMBL17660053 | 0.82 | CES2 (0.46) | CYP3A4CES2CES1IDO1TDO2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 81 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112625776-A | Graphene compound for lubricating oil additive and preparation method and application thereof | 中国石油化工股份有限公司 | 2021-04-09 | — | — | CN | claimed |
| US-20240124408-A1 | Substituted Cyclohexanecarboxamides, Their Preparation and Their Therapeutic Application | SANOFI (FR) | 2024-04-18 | — | — | US | disclosed |
| CN-110105346-B | Optionally substituted quinoline compounds | 卫材R&D管理有限公司 | 2023-03-10 | — | — | CN | disclosed |
| CN-112625776-B | Graphene compound for lubricating oil additive and preparation method and application thereof | 中国石油化工股份有限公司 | 2022-07-19 | — | — | CN | disclosed |
| EP-3995495-A1 | SELECTIVELY SUBSTITUTED QUINOLINE COMPOUNDS | Eisai R&D Management Co., Ltd. (JP) | 2022-05-11 | — | — | EP | disclosed |
| CN-112625776-A | Graphene compound for lubricating oil additive and preparation method and application thereof | 中国石油化工股份有限公司 | 2021-04-09 | — | — | CN | disclosed |
| EP-3626717-A1 | SELECTIVELY SUBSTITUTED QUINOLINE COMPOUNDS | Eisai R&D Management Co., Ltd. (JP) | 2020-03-25 | — | — | EP | disclosed |
| CN-110105346-A | Optionally substituted quinoline compounds | 卫材R&D管理有限公司 | 2019-08-09 | — | — | CN | disclosed |
| CN-106414432-B | Optionally substituted quinoline compounds | 卫材R&D管理有限公司 | 2019-06-14 | — | — | CN | disclosed |
| US-RE47193-E1 | Selectively substituted quinoline compounds | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2019-01-08 | — | — | US | disclosed |
| US-4338333-A | ANTIOBESITY, HYPOGLYCEMIC | BEECHAM GROUP LIMITED (GB) | 1982-07-06 | — | — | US | disclosed |
| EP-0052963-A1 | Secondary amines | BEECHAM GROUP PLC (GB) | 1982-06-02 | — | — | EP | disclosed |
| US-4309443-A | ANTI-OBESITY, HYPOGLYCEMIC | BEECHAM GROUP LIMITED (GB) | 1982-01-05 | — | — | US | disclosed |
| EP-0040000-A1 | Arylethanolamine derivatives, their preparation and use in pharmaceutical compositions | BEECHAM GROUP PLC (GB) | 1981-11-18 | — | — | EP | disclosed |
| EP-0025331-A1 | Cinnamic acid derivatives, their preparation, and pharmaceutical compositions containing them | BEECHAM GROUP PLC (GB) | 1981-03-18 | — | — | EP | disclosed |
| EP-0023385-A1 | Ethanamine derivatives, their preparation and use in pharmaceutical compositions | BEECHAM GROUP PLC (GB) | 1981-02-04 | — | — | EP | disclosed |
| EP-0021636-A1 | Secondary amines, their preparation and use in pharmaceutical compositions | BEECHAM GROUP PLC (GB) | 1981-01-07 | — | — | EP | disclosed |
| US-4224224-A | Certain 1-(carbocyclic aryl)-1-halo(or mesyloxy or tosyloxy)-2-(3'-alkoxycarbonylguanidino) ethanes | SYNTEX (U.S.A.) INC. (US) | 1980-09-23 | — | — | US | disclosed |
| US-4172204-A | Method for preparing 4,5-dihydro-2-alkoxycarbonylamino-5-carbocyclic aryl imidazoles and intermediates thereof | SYNTEX (U.S.A.) INC. (US) | 1979-10-23 | — | — | US | disclosed |
| EP-0001500-A1 | 1-Carbocyclic aryl-2-mono or -bis(alkoxycarbonyl) guanidino ethanes, and methods for their preparation and the preparation therefrom of 4,5-dihydro-2-alkoxycarbonylamino-5-carbocyclic aryl imidazoles | SYNTEX (U.S.A.) INC. (US) | 1979-04-18 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240124408-A1 | Substituted Cyclohexanecarboxamides, Their Preparation and Their Therapeutic Application | TRPM8, TAS2R8, TRPM7 | ADRA2C 465/4885ADRA1A 453/4885ADRB2 577/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.