Sugi Predict

Sugi Predict / Compounds / SCHEMBL4230481

SCHEMBL4230481

SCHEMBL4230481

CCCC(=O)c1ccccc1N

nearest known ligand 0.55

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 9/20 0.55
▸ HSD17B10 Q99714 6/20 0.55
▸ KDM4E B2RXH2 5/20 0.50
▸ CFTR P13569 1/20 0.50
▸ POLB P06746 1/20 0.50
▸ HPGD P15428 5/20 0.47
▸ SMN1; SMN2 Q16637 1/20 0.47
▸ L3MBTL1 Q9Y468 1/20 0.47
▸ GAA P10253 1/20 0.47
▸ MAPT P10636 1/20 0.47
▸ TSHR P16473 2/20 0.46
▸ ALOX15 P16050 1/20 0.46
▸ RECQL P46063 1/20 0.46
▸ TDP1 Q9NUW8 1/20 0.46
▸ LMNA P02545 1/20 0.45
▸ HSD17B3 P37058 1/20 0.42
▸ TP53 P04637 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1207100 0.89 ALDH1A1 (0.58) ALDH1A1HSD17B10KDM4ECFTRPOLB
SCHEMBL30484132 0.89 ALDH1A1 (0.58) ALDH1A1HSD17B10KDM4ECFTRPOLB
SCHEMBL312279 0.87 ALDH1A1 (0.58) ALDH1A1HSD17B10KDM4ECFTRPOLB
SCHEMBL28685165 0.85 ALDH1A1 (0.60) ALDH1A1HSD17B10KDM4EPOLBMAPT
SCHEMBL27397628 0.85 ALDH1A1 (0.60) ALDH1A1HSD17B10KDM4EPOLBMAPT
SCHEMBL27591991 0.85 ALDH1A1 (0.60) ALDH1A1HSD17B10KDM4EPOLBMAPT
SCHEMBL9631839 0.85 ALDH1A1 (0.43) ALDH1A1HSD17B10KDM4ECFTRPOLB
Water SCHEMBL27519090 0.84 ALDH1A1 (0.59) ALDH1A1HSD17B10KDM4EPOLBMAPT
Kynuramine SCHEMBL2801613 0.83 MAPT (0.50) ALDH1A1HSD17B10KDM4ECFTRPOLB
Kynuramine SCHEMBL30555814 0.83 MAPT (0.50) ALDH1A1HSD17B10KDM4ECFTRPOLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 40 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-63277678-A — — None — — JP disclosed
JP-62123170-A — — None — — JP disclosed
US-20240024490-A1 BIFUNCTIONAL MOLECULES FOR SELECTIVE MODIFICATION OF TARGET SUBSTRATES THE BROAD INSTITUTE, INC. 2024-01-25 — — US disclosed
US-20240024490-A1 BIFUNCTIONAL MOLECULES FOR SELECTIVE MODIFICATION OF TARGET SUBSTRATES THE BROAD INSTITUTE, INC. 2024-01-25 — — US disclosed
US-20230192904-A1 BIFUNCTIONAL CHIMERIC MOLECULES FOR LABELING OF KINASES WITH TARGET BINDING MOIETIES AND METHODS OF USE THEREOF THE BROAD INSTITUTE, INC. 2023-06-22 — — US disclosed
CN-115666575-A Compound and use thereof 福宏治疗公司 2023-01-31 — — CN disclosed
CN-104803894-B 2-aminobenzaldehyde oxime derivative and preparation method and application thereof 长庚大学 2017-04-12 — — CN disclosed
US-20150210636-A1 OXIME-BASED COMPOUND, PHARMACEUTICAL COMPOSITION CONTAINING THE SAME AND METHOD FOR PREPARING THE SAME CHANG GUNG UNIVERSITY (TW) 2015-07-30 — — US disclosed
US-20150210636-A1 OXIME-BASED COMPOUND, PHARMACEUTICAL COMPOSITION CONTAINING THE SAME AND METHOD FOR PREPARING THE SAME CHANG GUNG UNIVERSITY (TW) 2015-07-30 — — US disclosed
US-9073833-B1 Oxime-based compound, pharmaceutical composition containing the same and method for preparing the same CHANG GUNG UNIVERSITY (TW) 2015-07-07 — — US disclosed
US-6528505-B1 Treating Alzheimer's disease;5-(S)-(N'-(L-prolyl)-L-alaninyl)-amino-7-methyl-5,7-di hydro-6H- dibenz(b,d)azepin-one ELAN PHARMACEUTICALS, INC. 2003-03-04 — — US disclosed
EP-0852224-B1 Aryne intermediates towards the preparation of herbicidal sulfamoyl urea and a process for their preparation AMERICAN CYANAMID CO (US) 2001-10-31 — — EP disclosed
EP-0852224-A1 Aryne intermediates towards the preparation of herbicidal sulfamoyl urea and a process for their preparation American Cyanamid Company (US) 1998-07-08 — — EP disclosed
EP-0471358-B1 Fluoroethylcamptothecin derivatives KYORIN SEIYAKU KK (JP) 1996-05-08 — — EP disclosed
EP-0471358-A1 Fluoroethylcamptothecin derivatives KYORIN PHARMACEUTICAL CO., LTD. (JP) 1992-02-19 — — EP disclosed
JP-S63277678-A RADIOACTIVE 2-BROMOBUTYROPHENONE DERIVATIVE AND PRODUCTION THEREOF SUMITOMO CHEM CO LTD 1988-11-15 — — JP disclosed
JP-S62123170-A 2-IODOBUTYROPHENONE DERIVATIVE AND PRODUCTION THEREOF SUMITOMO CHEM CO LTD 1987-06-04 — — JP disclosed
US-4482681-A HYDRATED SALT HERCULES INCORPORATED (US) 1984-11-13 — — US disclosed
US-4075346-A CNS depressant γ-(secondary amino)-ortho-nitro-butyrophenones SUMITOMO CHEMICAL COMPANY, LIMITED (JA) 1978-02-21 — — US disclosed
US-3987047-A ANORETICS BOEHRINGER INGELHEIM GMBH (DT) 1976-10-19 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150210636-A1 OXIME-BASED COMPOUND, PHARMACEUTICAL COMPOSITION CONTAINING THE SAME AND METHOD FOR PREPARING THE SAME OR10J3, CYP3A4, CYP4B1 ALDH1A1 1743/4885HSD17B10 808/4885KDM4E 185/4885
US-20240024490-A1 BIFUNCTIONAL MOLECULES FOR SELECTIVE MODIFICATION OF TARGET SUBSTRATES COASY, JMJD7, PTMS ALDH1A1 1238/4885HSD17B10 527/4885KDM4E 2788/4885
US-20230192904-A1 BIFUNCTIONAL CHIMERIC MOLECULES FOR LABELING OF KINASES WITH TARGET BINDING MOIETIES AND METHODS OF USE THEREOF ERBB2, ACP1, TK1 ALDH1A1 2221/4885HSD17B10 3033/4885KDM4E 2301/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.