Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.67 |
| ▸ | HTT | P42858 | 1/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.62 |
| ▸ | LMNA | P02545 | 2/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.60 |
| ▸ | HPGD | P15428 | 1/20 | 0.60 |
| ▸ | TSHR | P16473 | 3/20 | 0.59 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.59 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.59 |
| ▸ | CNR1 | P21554 | 1/20 | 0.59 |
| ▸ | CNR2 | P34972 | 1/20 | 0.59 |
| ▸ | POLB | P06746 | 2/20 | 0.58 |
| ▸ | GAA | P10253 | 2/20 | 0.58 |
| ▸ | TLR2 | O60603 | 4/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.56 |
| ▸ | TP53 | P04637 | 1/20 | 0.55 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3806687 | 0.84 | MAPT (0.77) | MAPTHTTALDH1A1LMNAKDM4E | |
| SCHEMBL5451004 | 0.83 | MAPT (0.77) | MAPTHTTALDH1A1LMNAKDM4E | |
| SCHEMBL13631326 | 0.83 | KDM4E (0.53) | MAPTHTTALDH1A1LMNAKDM4E | |
| SCHEMBL4084306 | 0.80 | CNR1 (0.69) | MAPTHTTALDH1A1LMNAKDM4E | |
| SCHEMBL13764945 | 0.79 | KIF11 (0.49) | MAPTHTTALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL8292134 | 0.79 | MAPT (0.73) | MAPTHTTALDH1A1LMNAKDM4E | |
| SCHEMBL5806460 | 0.79 | ALDH1A1 (0.75) | MAPTHTTALDH1A1LMNAKDM4E | |
| SCHEMBL12057611 | 0.79 | KIF11 (0.53) | MAPTALDH1A1KDM4ESMN1; SMN2HPGD | |
| SCHEMBL12057618 | 0.79 | KIF11 (0.53) | MAPTALDH1A1KDM4ESMN1; SMN2HPGD | |
| SCHEMBL12057593 | 0.79 | KIF11 (0.53) | MAPTALDH1A1KDM4ESMN1; SMN2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2583963-A1 | Proline analogs as ligands for cannabinoid receptors for the treatment of pain | Purdue Pharma L.P. (US) | 2013-04-24 | — | — | EP | disclosed |
| US-8084612-B2 | Proline analogs as ligands for cannabinoid receptors | PURDUE PHARMA L.P. (US) | 2011-12-27 | — | — | US | disclosed |
| US-20090291947-A1 | PROLINE ANALOGS AS LIGANDS FOR CANNABINOID RECEPTORS | PURDUE PHARMA L.P. (US) | 2009-11-26 | — | — | US | disclosed |
| WO-2009087564-A1 | PROLINE ANALOGS AS LIGANDS FOR CANNABINOID RECEPTORS FOR THE TREATMENT OF PAIN | PURDUE PHARMA L.P. (DE) | 2009-07-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090291947-A1 | PROLINE ANALOGS AS LIGANDS FOR CANNABINOID RECEPTORS | CNR1, CNR2, GPR18 | MAPT 2443/4885HTT 2652/4885ALDH1A1 2632/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.