Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 8/20 | 0.47 |
| ▸ | NR3C2 | P08235 | 5/20 | 0.45 |
| ▸ | NR3C1 | P04150 | 4/20 | 0.45 |
| ▸ | AR | P10275 | 3/20 | 0.45 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.42 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
| ▸ | DRD3 | P35462 | 1/20 | 0.37 |
| ▸ | HTR6 | P50406 | 1/20 | 0.37 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.36 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.36 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.36 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.36 |
| ▸ | HSPE1 | P61604 | 1/20 | 0.36 |
| ▸ | BACE1 | P56817 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | BCL2 | P10415 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3025036 | 0.85 | NR3C2 (0.48) | PGRNR3C2NR3C1ARTNIK | |
| SCHEMBL3017159 | 0.85 | KIF11 (0.49) | NR3C2NR3C1ADRA1DADRA1A | |
| SCHEMBL12081775 | 0.85 | CYP17A1 (0.45) | NR3C2NR3C1THRBADRA1DADRA1A | |
| SCHEMBL12081678 | 0.83 | KIF11 (0.52) | NR3C2NR3C1ARSLC22A12ADRA1D | |
| SCHEMBL14666667 | 0.82 | EGLN2 (0.39) | PGRNR3C2NR3C1ARBACE1 | |
| SCHEMBL12081699 | 0.81 | GLO1 (0.40) | PGRNR3C2ADRA1DADRA1A | |
| SCHEMBL3027015 | 0.80 | NR3C2 (0.39) | NR3C2TNIKADRA1A | |
| SCHEMBL3022634 | 0.80 | CYP17A1 (0.45) | NR3C2ADRA1DADRA1A | |
| SCHEMBL3026326 | 0.79 | CYP17A1 (0.39) | NR3C2ADRA1DADRA1A | |
| SCHEMBL12081721 | 0.79 | KIF11 (0.39) | PGRNR3C2NR3C1ARDRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8410166-B2 | Fused bicyclic compound | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2013-04-02 | — | — | US | disclosed |
| US-8258131-B2 | Fused bicyclic compound | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2012-09-04 | — | — | US | disclosed |
| US-8258131-B2 | Fused bicyclic compound | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2012-09-04 | — | — | US | disclosed |
| US-20100204218-A1 | FUSED BICYCLIC COMPOUND | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2010-08-12 | — | — | US | disclosed |
| US-20100204218-A1 | FUSED BICYCLIC COMPOUND | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2010-08-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100204218-A1 | FUSED BICYCLIC COMPOUND | NR3C2, NR3C1, MC2R | PGR 215/4885NR3C2 1/4885NR3C1 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.