Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.37 |
| ▸ | LDHA | P00338 | 1/20 | 0.36 |
| ▸ | CTSS | P25774 | 1/20 | 0.35 |
| ▸ | CTSK | P43235 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.33 |
| ▸ | CTSG | P08311 | 1/20 | 0.33 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.33 |
| ▸ | CMA1 | P23946 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9382586 | 0.86 | SMN1; SMN2 (0.41) | SMN1; SMN2RAB9AALDH1A1LMNAKMT2A | |
| SCHEMBL2578175 | 0.86 | SMN1; SMN2 (0.39) | SMN1; SMN2NPC1RECQLRAB9AAAK1 | |
| SCHEMBL642839 | 0.86 | SMN1; SMN2 (0.41) | SMN1; SMN2RAB9AALDH1A1LMNAKMT2A | |
| SCHEMBL6832851 | 0.85 | USP30 (0.32) | LMNAPRSS1CTSGCTRB1CMA1 | |
| SCHEMBL8364820 | 0.85 | MT-CO2 (0.45) | SMN1; SMN2LMNAKMT2AMEN1CYP2D6 | |
| SCHEMBL5846260 | 0.85 | KMT2A (0.40) | NPC1CTSSCTSKLMNAKMT2A | |
| SCHEMBL2276227 | 0.85 | MT-CO2 (0.45) | SMN1; SMN2LMNAKMT2AMEN1CYP2D6 | |
| SCHEMBL10521312 | 0.85 | NR1H2 (0.34) | NPC1RAB9AAAK1ALDH1A1LMNA | |
| SCHEMBL4648001 | 0.85 | MT-CO2 (0.45) | SMN1; SMN2LMNAKMT2AMEN1CYP2D6 | |
| SCHEMBL10431533 | 0.84 | KEAP1 (0.42) | SMN1; SMN2NPC1RAB9ALDHAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110046105-A1 | Heterocycle-substituted imidazolidine-2,4-diones, process for preparation thereof, medicaments comprising them and use thereof | SANOFI-AVENTIS (FR) | 2011-02-24 | — | — | US | disclosed |
| CN-1753673-B | Prodrugs of GABA analogs, compositions and uses thereof | XENOPORT INC | 2010-09-29 | — | — | CN | disclosed |
| CN-1753673-A | Prodrugs of gaba analogs, compositions and uses thereof | XENOPORT INC (US) | 2006-03-29 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110046105-A1 | Heterocycle-substituted imidazolidine-2,4-diones, process for preparation thereof, medicaments comprising them and use thereof | GIPR, DDC, PGC | SMN1; SMN2 4621/4885NPC1 2432/4885RECQL 161/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.