Quazinone

Quazinone

SCHEMBL120977

C[C@@H]1C(=O)N=C2Nc3cccc(Cl)c3CN21

nearest known ligand 0.62

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PDE3B Q13370 3/20 0.62
PDE3A Q14432 3/20 0.62
LMNA P02545 1/20 0.62
CYP1A2 P05177 1/20 0.62
CYP3A4 P08684 1/20 0.62
CYP2D6 P10635 1/20 0.62
TSHR P16473 1/20 0.62
BLM P54132 1/20 0.62
MMP13 P45452 2/20 0.41
ACE P12821 1/20 0.41
CDK5 Q00535 1/20 0.41
CDK5R1 Q15078 1/20 0.41
HTR5A P47898 6/20 0.38
HTR1A P08908 4/20 0.38
HTR1D P28221 4/20 0.38
HTR2C P28335 4/20 0.38
HTR7 P34969 4/20 0.38
HTR2A P28223 2/20 0.38
HTR3A P46098 2/20 0.38
HTR6 P50406 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Quazinone SCHEMBL25297639 1.00 PDE3B (0.62) PDE3BPDE3ALMNACYP1A2CYP3A4
Quazinone SCHEMBL2463520 0.76 PDE3B (1.00) PDE3BPDE3ALMNACYP1A2CYP3A4
Quazinone SCHEMBL120976 0.76 PDE3B (1.00) PDE3BPDE3ALMNACYP1A2CYP3A4
Quazinone SCHEMBL11279841 0.75 PDE3B (0.97) PDE3BPDE3ALMNACYP1A2CYP3A4
SCHEMBL4578707 0.71 PDE3B (0.62) PDE3BPDE3ALMNACYP1A2CYP3A4
SCHEMBL11821637 0.68 PDE3B (0.62) PDE3BPDE3ALMNACYP1A2CYP3A4
SCHEMBL3963853 0.68 ACE (0.46) PDE3BPDE3ALMNACYP1A2CYP3A4
SCHEMBL21257756 0.67 MMP13 (0.51) LMNACYP2D6MMP13ACECDK5
SCHEMBL11278398 0.67 PDE3B (0.70) PDE3BPDE3ALMNACYP1A2CYP3A4
Hydrochloric Acid SCHEMBL11388525 0.66 PDE3B (0.68) PDE3BPDE3ALMNACYP1A2CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 807 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11903992-B2 Composition comprising lidocaine, l-carnosine and dexpanthenol CELLIX BIO PRIVATE LIMITED (IN) 2024-02-20 US claimed
WO-2023118113-A1 COMPOUNDS TIRAPAZAMINE AND QUAZINONE FOR USE IN THE TREATMENT OF GM2 GANGLIOSIDOSES SOM INNOVATION BIOTECH, S.A. (ES) 2023-06-29 WO claimed
EP-4201403-A1 COMPOUNDS TIRAPAZAMINE AND QUAZINONE FOR USE IN THE TREATMENT OF GM2 GANGLIOSIDOSES Som Innovation Biotech, S.L. (ES) 2023-06-28 EP claimed
WO-2022190030-A1 A TOPICAL FORMULATION FOR THE TREATMENT OF SKIN DISEASES AVACA PHARMA PRIVATE LIMITED (IN) 2022-09-15 WO claimed
WO-2022157587-A1 A COMPOSITION COMPRISING LIDOCAINE, L-CARNOSINE AND DEXPANTHENOL CELLIX BIO PRIVATE LIMITED (IN) 2022-07-28 WO claimed
US-20220233629-A1 COMPOSITION COMPRISING LIDOCAINE, L-CARNOSINE AND DEXPANTHENOL CELLIX BIO PRIVATE LIMITED (IN) 2022-07-28 US claimed
US-20220184052-A1 COMPOSITION COMPRISING FEXOFENADINE CELLIX BIO PRIVATE LIMITED (IN) 2022-06-16 US claimed
WO-2022123511-A1 A COMPOSITION COMPRISING FEXOFENADINE CELLIX BIO PRIVATE LIMITED (IN) 2022-06-16 WO claimed
EP-2704560-B1 ORGAN CARE SOLUTION FOR EX-VIVO MACHINE PERFUSION OF DONOR LUNGS TRANSMEDICS INC (US) 2022-04-06 EP claimed
US-20190046528-A1 METHOD OF PREVENTING HAIR LOSS OR PROMOTING HAIR GROWTH BY USING PHOSPHODIESTERASE 3 INHIBITOR SEOUL NATIONAL UNIVERSITY HOSPITAL (KR) 2019-02-14 US claimed
US-20020004498-A1 Transmucosal administration of phosphodiesterase inhibitors for the treatment of erectile dysfunction DOHERTY PAUL C (US) 2002-01-10 US claimed
EP-0777482-B1 COMBINED PREPARATION FOR THE THERAPY OF IMMUNE DISEASES HOECHST AG (DE) 2001-11-14 EP claimed
US-6297243-B1 TREATING OSTEOPENIA THAT ACCOMPANIES THE MENOPAUSE NOVO NORDISK A/S (DK) 2001-10-02 US claimed
WO-2001041807-A2 TRANSMUCOSAL COMPOSITION CONTAINING A PHOSPHODIESTERASE INHIBITORS FOR THE TREATMENT OF ERECTILE DYSFUNCTION VIVUS, INC. (US) 2001-06-14 WO claimed
US-6156753-A Local administration of type III phosphodiesterase inhibitors for the treatment of erectile dysfunction VIVUS, INC. (US) 2000-12-05 US claimed
US-6110471-A ADMINISTERING PHOSPHODIESTERASE FOR INHIBITION OF THE CYCLES THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) 2000-08-29 US claimed
EP-1028690-A2 LUTEINISING HORMONE ANTAGONISTS USEFUL FOR TREATMENT OF ESTROGEN DEFICIENCIES, OR AS A CONTRACEPTIVE NOVO NORDISK A/S (DK) 2000-08-23 EP claimed
EP-1012188-A1 COMPOSITION FOR TREATING DIABETES MELLITUS AND OBESITY FORSSMANN, Wolf-Georg, Prof. Dr. (DE) 2000-06-28 EP claimed
WO-1999020223-A2 LUTEINISING HORMONE ANTAGONISTS USEFUL FOR TREATMENT OF ESTROGEN DEFICIENCIES, OR AS A CONTRACEPTIVE NOVO NORDISK A/S (DK) 1999-04-29 WO claimed
WO-1999014239-A1 COMPOSITION FOR TREATING DIABETES MELLITUS AND OBESITY FORSSMANN WOLF GEORG (DE) 1999-03-25 WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020004498-A1 Transmucosal administration of phosphodiesterase inhibitors for the treatment of erectile dysfunction PDE3A, PDE5A, PDE3B PDE3B 3/4885PDE3A 1/4885LMNA 3009/4885
US-11903992-B2 Composition comprising lidocaine, l-carnosine and dexpanthenol VNN1, LPL, HMGB1 PDE3B 837/4885PDE3A 296/4885LMNA 16/4885
US-20220233629-A1 COMPOSITION COMPRISING LIDOCAINE, L-CARNOSINE AND DEXPANTHENOL VNN1, LPL, HMGB1 PDE3B 837/4885PDE3A 296/4885LMNA 16/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.