Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.53 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.53 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.53 |
| ▸ | CA2 | P00918 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | SNCA | P37840 | 1/20 | 0.49 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.48 |
| ▸ | ESR1 | P03372 | 1/20 | 0.47 |
| ▸ | GCGR | P47871 | 1/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | PLAU | P00749 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | PLK1 | P53350 | 3/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | TOP1 | P11387 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22323667 | 0.85 | HDAC6 (0.53) | HDAC6HDAC8HDAC2CA2MAPT | |
| SCHEMBL328702 | 0.82 | HDAC6 (0.67) | HDAC6HDAC8HDAC2CA2MAPT | |
| SCHEMBL18329647 | 0.81 | SMN1; SMN2 (0.61) | HDAC6HDAC8HDAC2HPGDTSHR | |
| SCHEMBL2648578 | 0.81 | OGG1 (0.57) | HDAC6CA2MAPTSNCAESR1 | |
| SCHEMBL3819667 | 0.79 | HDAC6 (0.52) | HDAC6HDAC8HDAC2CA2THRB | |
| SCHEMBL4176796 | 0.79 | HDAC8 (0.52) | HDAC6HDAC8HDAC2CA2MAPT | |
| SCHEMBL30362187 | 0.79 | HDAC6 (0.52) | HDAC6HDAC8HDAC2CA2THRB | |
| SCHEMBL12218136 | 0.78 | HDAC6 (0.50) | HDAC6HDAC8HDAC2CA2ESR1 | |
| SCHEMBL985272 | 0.78 | PKM (0.55) | CA2MAPTESR1HTTSMN1; SMN2 | |
| SCHEMBL29748630 | 0.77 | ALDH1A1 (0.53) | HDAC6CA2MAPTSNCAESR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2937344-B1 | PYRIDINYL- AND PYRAZINYL -METHYLOXY - ARYL DERIVATIVES USEFUL AS INHIBITORS OF SPLEEN TYROSINE KINASE (SYK) | GLAXO GROUP LTD (GB) | 2017-08-23 | — | — | EP | disclosed |
| EP-2937344-B1 | PYRIDINYL- AND PYRAZINYL -METHYLOXY - ARYL DERIVATIVES USEFUL AS INHIBITORS OF SPLEEN TYROSINE KINASE (SYK) | GLAXO GROUP LTD (GB) | 2017-08-23 | — | — | EP | disclosed |
| US-20160355505-A1 | NOVEL COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2016-12-08 | — | — | US | disclosed |
| US-20160355505-A1 | NOVEL COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2016-12-08 | — | — | US | disclosed |
| US-9447074-B2 | Compounds | GLAXO GROUP LIMITED (GB) | 2016-09-20 | — | — | US | disclosed |
| US-9447074-B2 | Compounds | GLAXO GROUP LIMITED (GB) | 2016-09-20 | — | — | US | disclosed |
| EP-2937344-A1 | PYRIDINYL- AND PYRAZINYL -METHYLOXY - ARYL DERIVATIVES USEFUL AS INHIBITORS OF SPLEEN TYROSINE KINASE (SYK) | Glaxo Group Limited (GB) | 2015-10-28 | — | — | EP | disclosed |
| EP-2937344-A1 | PYRIDINYL- AND PYRAZINYL -METHYLOXY - ARYL DERIVATIVES USEFUL AS INHIBITORS OF SPLEEN TYROSINE KINASE (SYK) | Glaxo Group Limited (GB) | 2015-10-28 | — | — | EP | disclosed |
| US-20150166508-A1 | NOVEL COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2015-06-18 | — | — | US | disclosed |
| US-20150166508-A1 | NOVEL COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2015-06-18 | — | — | US | disclosed |
| EP-2683709-B1 | PYRIDINYL- AND PYRAZINYL-METHYLOXY-ARYL DERIVATIVES USEFUL AS INHIBITORS OF SPLEEN TYROSINE KINASE (SYK) | GLAXO GROUP LTD (GB) | 2015-05-06 | — | — | EP | disclosed |
| EP-2683709-B1 | PYRIDINYL- AND PYRAZINYL-METHYLOXY-ARYL DERIVATIVES USEFUL AS INHIBITORS OF SPLEEN TYROSINE KINASE (SYK) | GLAXO GROUP LTD (GB) | 2015-05-06 | — | — | EP | disclosed |
| US-8993560-B2 | Compounds | GLAXO GROUP LIMITED (GB) | 2015-03-31 | — | — | US | disclosed |
| US-8993560-B2 | Compounds | GLAXO GROUP LIMITED (GB) | 2015-03-31 | — | — | US | disclosed |
| US-20140005177-A1 | PYRIDINYL- AND PYRAZINYL-METHYLOXY-ARYL DERIVATIVES USEFUL AS INHIBITORS OF SPLEEN TYROSINE KINASE (SYK) | GLAXO GROUP LIMITED (GB) | 2014-01-02 | — | — | US | disclosed |
| WO-2012123311-A1 | PYRIDINYL- AND PYRAZINYL -METHYLOXY - ARYL DERIVATIVES USEFUL AS INHIBITORS OF SPLEEN TYROSINE KINASE (SYK) | GLAXO GROUP LIMITED (GB) | 2012-09-20 | — | — | WO | disclosed |
| US-20120232061-A1 | NOVEL COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2012-09-13 | — | — | US | disclosed |
| US-20120232061-A1 | NOVEL COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2012-09-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150166508-A1 | NOVEL COMPOUNDS | SYK, NFATC1, BTK | HDAC6 1202/4885HDAC8 2329/4885HDAC2 1069/4885 |
| US-20140005177-A1 | PYRIDINYL- AND PYRAZINYL-METHYLOXY-ARYL DERIVATIVES USEFUL AS INHIBITORS OF SPLEEN TYROSINE KINASE (SYK) | SYK, MERTK, LCK | HDAC6 2196/4885HDAC8 2030/4885HDAC2 1278/4885 |
| US-20120232061-A1 | NOVEL COMPOUNDS | SYK, NFATC1, BTK | HDAC6 1202/4885HDAC8 2329/4885HDAC2 1069/4885 |
| US-20160355505-A1 | NOVEL COMPOUNDS | SYK, NFATC1, BTK | HDAC6 1202/4885HDAC8 2329/4885HDAC2 1069/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.