Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPA1 | P27694 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | KCNJ6 | P48051 | 6/20 | 0.46 |
| ▸ | KCNJ3 | P48549 | 6/20 | 0.46 |
| ▸ | KCNJ5 | P48544 | 5/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.43 |
| ▸ | PPP1CA | P62136 | 1/20 | 0.42 |
| ▸ | BCL2 | P10415 | 1/20 | 0.42 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.42 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | FAAH | O00519 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12100811 | 0.78 | RPA1 (0.51) | RPA1ALDH1A1L3MBTL1PPP1CABCL2 | |
| SCHEMBL12100441 | 0.76 | ALDH1A1 (0.57) | RPA1ALDH1A1L3MBTL1PPP1CABCL2 | |
| SCHEMBL12099955 | 0.76 | RPA1 (0.49) | RPA1ALDH1A1L3MBTL1RIPK1PPP1CA | |
| SCHEMBL12099956 | 0.75 | RPA1 (0.50) | RPA1ALDH1A1L3MBTL1PPP1CABCL2 | |
| SCHEMBL12100261 | 0.74 | ALDH1A1 (0.54) | RPA1ALDH1A1L3MBTL1PPP1CABCL2 | |
| SCHEMBL2320792 | 0.74 | RPA1 (0.49) | RPA1ALDH1A1L3MBTL1PPP1CABCL2 | |
| SCHEMBL4704813 | 0.73 | MAPT (0.60) | RPA1ALDH1A1KCNJ6KCNJ3KCNJ5 | |
| SCHEMBL12100316 | 0.72 | GAA (0.70) | RPA1MEN1KMT2A | |
| SCHEMBL12100454 | 0.72 | RPA1 (0.47) | RPA1ALDH1A1L3MBTL1PPP1CABCL2 | |
| SCHEMBL31587443 | 0.72 | RPA1 (0.56) | RPA1ALDH1A1L3MBTL1PPP1CABCL2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103459374-B | Amino-substituted 3-heteroaroylamino-propionic acid derivatives and their use as pharmaceuticals | SAI NUOFEI (FR) | 2015-11-25 | — | — | CN | disclosed |
| US-8962671-B2 | Amino-substituted 3-heteroaroylamino-propionic acid derivatives and their use as pharmaceuticals | SANOFI (FR) | 2015-02-24 | — | — | US | disclosed |
| US-8962671-B2 | Amino-substituted 3-heteroaroylamino-propionic acid derivatives and their use as pharmaceuticals | SANOFI (FR) | 2015-02-24 | — | — | US | disclosed |
| US-8962671-B2 | Amino-substituted 3-heteroaroylamino-propionic acid derivatives and their use as pharmaceuticals | SANOFI (FR) | 2015-02-24 | — | — | US | disclosed |
| EP-2668167-B1 | AMINO-SUBSTITUTED 3-HETEROAROYLAMINO-PROPIONIC ACID DERIVATIVES AND THEIR USE AS PHARMACEUTICALS | SANOFI SA (FR) | 2014-12-17 | — | — | EP | disclosed |
| CN-103459374-A | Amino-substituted 3-heteroaroylamino-propionic acid derivatives and their use as pharmaceuticals | SANOFI SA | 2013-12-18 | — | — | CN | disclosed |
| EP-2668167-A1 | AMINO-SUBSTITUTED 3-HETEROAROYLAMINO-PROPIONIC ACID DERIVATIVES AND THEIR USE AS PHARMACEUTICALS | SANOFI (FR) | 2013-12-04 | — | — | EP | disclosed |
| US-20120232112-A1 | AMINO-SUBSTITUTED 3-HETEROAROYLAMINO-PROPIONIC ACID DERIVATIVES AND THEIR USE AS PHARMACEUTICALS | SANOFI (FR) | 2012-09-13 | — | — | US | disclosed |
| US-20120232112-A1 | AMINO-SUBSTITUTED 3-HETEROAROYLAMINO-PROPIONIC ACID DERIVATIVES AND THEIR USE AS PHARMACEUTICALS | SANOFI (FR) | 2012-09-13 | — | — | US | disclosed |
| US-20120232112-A1 | AMINO-SUBSTITUTED 3-HETEROAROYLAMINO-PROPIONIC ACID DERIVATIVES AND THEIR USE AS PHARMACEUTICALS | SANOFI (FR) | 2012-09-13 | — | — | US | disclosed |
| WO-2012101199-A1 | AMINO-SUBSTITUTED 3-HETEROAROYLAMINO-PROPIONIC ACID DERIVATIVES AND THEIR USE AS PHARMACEUTICALS | SANOFI (FR) | 2012-08-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120232112-A1 | AMINO-SUBSTITUTED 3-HETEROAROYLAMINO-PROPIONIC ACID DERIVATIVES AND THEIR USE AS PHARMACEUTICALS | CTSF, CTSS, CTSE | RPA1 3960/4885ALDH1A1 862/4885KCNJ6 3355/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.