SCHEMBL12108751

SCHEMBL12108751

Cc1cnc2c(c1)C(=O)C(=O)c1cc(C)cnc1-2

nearest known ligand 0.66

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 1/20 0.66
CCR1 P32246 2/20 0.43
CCR5 P51681 2/20 0.43
CCR8 P51685 2/20 0.43
PTGS2 P35354 2/20 0.40
PTGS1 P23219 1/20 0.40
PDK2 Q15119 1/20 0.39
TDP2 O95551 1/20 0.38
NSD2 O96028 1/20 0.38
ABL1 P00519 1/20 0.38
PLCG1 P19174 1/20 0.38
CES1 P23141 1/20 0.38
PAX8 Q06710 1/20 0.38
RIN1 Q13671 1/20 0.38
NOS3 P29474 1/20 0.38
NOS1 P29475 1/20 0.38
NOS2 P35228 1/20 0.38
MAOB P27338 2/20 0.37
MAOA P21397 1/20 0.37
ELANE P08246 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13151876 0.95 KMT2A (0.71) KMT2ACCR1CCR5CCR8PTGS2
SCHEMBL6598757 0.91 KMT2A (0.66) KMT2ACCR1CCR5CCR8PTGS2
SCHEMBL16601623 0.85 TDP2 (0.66) KMT2ACCR1CCR5CCR8PTGS2
SCHEMBL16656189 0.84 KMT2A (0.54) KMT2ACCR1CCR5CCR8PTGS2
SCHEMBL13168837 0.81 KMT2A (0.56) KMT2ACCR1CCR5CCR8PTGS2
SCHEMBL8917379 0.80 KMT2A (0.86) KMT2APDK2TDP2MAOBELANE
SCHEMBL12110126 0.78 KMT2A (0.67) KMT2ACCR1CCR5CCR8PTGS2
SCHEMBL17339870 0.77 KMT2A (0.51) KMT2ACCR1CCR5CCR8PTGS2
SCHEMBL7478704 0.76 KMT2A (0.50) KMT2ACCR1CCR5CCR8PTGS2
SCHEMBL13940472 0.76 KMT2A (0.68) KMT2ACCR1CCR5CCR8PTGS2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8465889-B2 Electrophotographic photosensitive member, process cartridge, and electrophotographic apparatus CANON KABUSHIKI KAISHA (JP) 2013-06-18 US disclosed
US-8465889-B2 Electrophotographic photosensitive member, process cartridge, and electrophotographic apparatus CANON KABUSHIKI KAISHA (JP) 2013-06-18 US disclosed
US-8435706-B2 2013-05-07 US disclosed
US-8435706-B2 2013-05-07 US disclosed
US-20110268472-A1 ELECTROPHOTOGRAPHIC PHOTOSENSITIVE MEMBER, PROCESS CARTRIDGE, AND ELECTROPHOTOGRAPHIC APPARATUS CANON KABUSHIKI KAISHA (JP) 2011-11-03 US disclosed
US-20110268472-A1 ELECTROPHOTOGRAPHIC PHOTOSENSITIVE MEMBER, PROCESS CARTRIDGE, AND ELECTROPHOTOGRAPHIC APPARATUS CANON KABUSHIKI KAISHA (JP) 2011-11-03 US disclosed