Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.56 |
| ▸ | ESR1 | P03372 | 2/20 | 0.56 |
| ▸ | MEN1 | O00255 | 4/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.53 |
| ▸ | GFER | P55789 | 1/20 | 0.53 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | S100B | P04271 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL676344 | 0.85 | POLB (0.60) | POLBTDP1ESR1MEN1KMT2A | |
| SCHEMBL9806710 | 0.83 | RAB9A (0.65) | POLBTDP1ESR1MEN1KMT2A | |
| SCHEMBL1306810 | 0.78 | RAB9A (0.76) | POLBTDP1MEN1KMT2AGFER | |
| SCHEMBL17166274 | 0.78 | RAB9A (0.76) | POLBTDP1MEN1KMT2AGFER | |
| SCHEMBL10119800 | 0.78 | ESR1 (0.74) | POLBTDP1ESR1MEN1KMT2A | |
| SCHEMBL7567814 | 0.77 | ESR1 (0.72) | POLBTDP1ESR1MEN1KMT2A | |
| SCHEMBL17166046 | 0.75 | RAB9A (0.67) | POLBTDP1MEN1KMT2AMAPK1 | |
| SCHEMBL14016924 | 0.74 | CA9 (0.64) | POLBESR1MEN1KMT2AGFER | |
| SCHEMBL12112145 | 0.74 | S100B (0.83) | POLBTDP1MEN1KMT2ACTDSP1 | |
| SCHEMBL11246411 | 0.73 | POLB (0.77) | POLBTDP1MEN1KMT2ACTDSP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8053477-B2 | Including but hot limited to pentamidine and derivatives thereof | UNIVERSITY OF MARYLAND, BALTIMORE (US) | 2011-11-08 | — | — | US | disclosed |