Azaperone

Azaperone

SCHEMBL121134

O=C(CCCN1CCN(c2ccccn2)CC1)c1ccc(F)cc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ DRD4 P21917 13/20 1.00
▸ DRD2 P14416 13/20 1.00
▸ DRD3 P35462 13/20 1.00
▸ HTR1A P08908 12/20 1.00
▸ HTR2A P28223 11/20 1.00
▸ HTR7 P34969 10/20 1.00
▸ HTR2C P28335 8/20 1.00
▸ SIGMAR1 Q99720 8/20 1.00
▸ TMEM97 Q5BJF2 6/20 1.00
▸ LMNA P02545 1/20 1.00
▸ CYP1A2 P05177 1/20 1.00
▸ CYP3A4 P08684 1/20 1.00
▸ CYP2D6 P10635 1/20 1.00
▸ CYP2C9 P11712 1/20 1.00
▸ CYP2C19 P33261 1/20 1.00
▸ SMN1; SMN2 Q16637 1/20 1.00
▸ ADRA2C P18825 3/20 0.77
▸ HRH1 P35367 3/20 0.77
▸ SLC6A4 P31645 1/20 0.64
▸ DRD1 P21728 2/20 0.64

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Azaperone SCHEMBL29437229 1.00 DRD4 (1.00) DRD4DRD2DRD3HTR1AHTR2A
SCHEMBL6358772 0.93 DRD4 (0.87) DRD4DRD2DRD3HTR1AHTR2A
Azaperone SCHEMBL3087530 0.93 DRD4 (0.86) DRD4DRD2DRD3HTR1AHTR2A
SCHEMBL12436913 0.88 DRD4 (0.79) DRD4DRD2DRD3HTR1AHTR2A
SCHEMBL9631347 0.88 HTR1A (0.79) DRD4DRD2DRD3HTR1AHTR2A
SCHEMBL28925988 0.86 DRD2 (0.76) DRD4DRD2DRD3HTR1AHTR2A
SCHEMBL6353873 0.85 DRD4 (0.74) DRD4DRD2DRD3HTR1AHTR2A
SCHEMBL6354321 0.84 DRD4 (1.00) DRD4DRD2DRD3HTR1AHTR2A
SCHEMBL6358178 0.84 DRD4 (1.00) DRD4DRD2DRD3HTR1AHTR2A
SCHEMBL6354317 0.84 DRD4 (1.00) DRD4DRD2DRD3HTR1AHTR2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 2492 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025111482-A1 COMPLEXING AGENT SALT FORMULATIONS OF PHARMACEUTICAL COMPOUNDS AT LOW STOICHIOMETRIC RATIOS BEXSON BIOMEDICAL, INC. (US) 2025-05-30 — — WO claimed
US-12263178-B2 Pharmaceutical compositions and methods POP TEST ONCOLOGY LLC (US) 2025-04-01 — — US claimed
EP-4178948-A2 FUNCTIONALIZED ISONITRILES AND PRODUCTS, PREPARATION AND USES THEREOF Universidade de Santiago de Compostela (ES) 2023-05-17 — — EP claimed
US-20230142627-A1 PHARMACEUTICAL COMPOSITIONS AND METHODS POP TEST ONCOLOGY LLC (US) 2023-05-11 — — US claimed
CN-111116375-B Method for preparing primary amine by catalyzing aldehyde ketone compound through reductive amination 中国科学院广州能源研究所 2023-04-07 — — CN claimed
WO-2023049482-A1 METHODS OF TREATING RESTRICTIVE EATING DISORDERS ARVID THERAPEUTICS (US) 2023-03-30 — — WO claimed
CN-115754034-A Method for detecting content of sodium metabisulfite in azaperone injection 宁波三生生物科技股份有限公司 2023-03-07 — — CN claimed
US-11534375-B2 Solvent-free method of encapsulating a hydrophobic active AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) 2022-12-27 — — US claimed
CN-115201354-A Method for detecting illegally added 42 tranquilization medicines and antidepressant medicines in Chinese patent medicines and health-care products 广东省药品检验所(广东省药品质量研究所、广东省口岸药品检验所) 2022-10-18 — — CN claimed
CN-115128195-A LC-MS/MS detection method for pesticide and veterinary drug residues in animal oil and vegetable oil 北京市疾病预防控制中心 2022-09-30 — — CN claimed
US-6197764-B1 COMPLEX WITH FATTY ACID; THERAPY FOR PSYCHOLOGICAL DISORDERS PROTARGA, INC. 2001-03-06 — — US claimed
EP-1044023-A1 A COVALENT CONJUGATE OF CLOZAPINE WITH A FATTY ACID AND ITS USE FOR TREATING SCHIZOPHRENIA Protarga Inc. (US) 2000-10-18 — — EP claimed
US-5955459-A Fatty acid-antipsychotic compositions and uses thereof NEUROMEDICA, INC. (US) 1999-09-21 — — US claimed
WO-1999026661-A1 A COVALENT CONJUGATE OF CLOZAPINE WITH A FATTY ACID AND ITS USE FOR TREATING SCHIZOPHRENIA PROTARGA INC. (US) 1999-06-03 — — WO claimed
US-5785976-A Solid lipid particles, particles of bioactive agents and methods for the manufacture and use thereof PHARMACIA & UPJOHN AB (SE) 1998-07-28 — — US claimed
EP-0687362-A1 SELECTIVE BINDING MATERIALS AND ASSAYS MINISTER OF AGRICULTURE FISHERIES AND FOOD IN HER BRITANNIC MAJESTY'S GOV. OF THE U.K. OF GREAT BRITAIN AND NORTHERN IRELAND (GB) 1995-12-20 — — EP claimed
WO-1994020854-A1 SELECTIVE BINDING MATERIALS AND ASSAYS THE MINISTER OF AGRICULTURE FISHERIES AND FOOD IN HER BRITANNIC MAJESTY'S GOVERNMENT OF THE UNITED KINGDOM OF GREAT BRITAIN AND NORTHERN IRELAND (GB) 1994-09-15 — — WO claimed
US-4508715-A DOPAMINE ANTAGONISTS;OVERDOSE TREATMENT UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. (US) 1985-04-02 — — US claimed
EP-0105361-A1 ANTAGONISM OF CENTRAL NERVOUS SYSTEM DRUGS BY THE ADMINISTRATION OF 4-AMINOPYRIDINE ALONE OR IN COMBINATION WITH OTHER DRUGS THE UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. (US) 1984-04-18 — — EP claimed
WO-1983003541-A1 ANTAGONISM OF CENTRAL NERVOUS SYSTEM DRUGS BY THE ADMINISTRATION OF 4-AMINOPYRIDINE ALONE OR IN COMBINATION WITH OTHER DRUGS UNIV GEORGIA RES FOUND (US) 1983-10-27 — — WO claimed
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