Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 8/20 | 0.79 |
| ▸ | DRD4 | P21917 | 8/20 | 0.79 |
| ▸ | HTR2A | P28223 | 7/20 | 0.79 |
| ▸ | DRD3 | P35462 | 7/20 | 0.79 |
| ▸ | HTR7 | P34969 | 6/20 | 0.79 |
| ▸ | DRD2 | P14416 | 6/20 | 0.79 |
| ▸ | HTR2C | P28335 | 6/20 | 0.79 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.79 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.79 |
| ▸ | LMNA | P02545 | 1/20 | 0.79 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.79 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.79 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.79 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.79 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.79 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.79 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.61 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.59 |
| ▸ | HRH1 | P35367 | 1/20 | 0.59 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Azaperone SCHEMBL121134 | 0.88 | DRD4 (1.00) | HTR1ADRD4HTR2ADRD3HTR7 | |
| SCHEMBL12436913 | 0.88 | DRD4 (0.79) | HTR1ADRD4HTR2ADRD3HTR7 | |
| Azaperone SCHEMBL29437229 | 0.88 | DRD4 (1.00) | HTR1ADRD4HTR2ADRD3HTR7 | |
| SCHEMBL9631680 | 0.87 | HTR1A (0.71) | HTR1ADRD4HTR2ADRD3HTR7 | |
| SCHEMBL9633626 | 0.86 | HTR1A (0.77) | HTR1ADRD4HTR2ADRD3HTR7 | |
| SCHEMBL6351416 | 0.85 | HTR1A (1.00) | HTR1ADRD4HTR2ADRD3HTR7 | |
| SCHEMBL3674700 | 0.83 | HTR1A (0.72) | HTR1ADRD4HTR2ADRD3HTR7 | |
| Azaperone SCHEMBL3087530 | 0.82 | DRD4 (0.86) | HTR1ADRD4HTR2ADRD3HTR7 | |
| SCHEMBL9631705 | 0.81 | HTR1A (0.66) | HTR1ADRD4HTR2ADRD3HTR7 | |
| SCHEMBL27237004 | 0.81 | DRD3 (1.00) | HTR1ADRD4HTR2ADRD3HTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5089497-A | Dopaminergic agents | WARNER-LAMBERT COMPANY (US) | 1992-02-18 | — | — | US | claimed |
| US-5089497-A | Dopaminergic agents | WARNER-LAMBERT COMPANY (US) | 1992-02-18 | — | — | US | disclosed |