Known targets — ChEMBL curated mechanism
ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3CHRM1CHRM2CHRM3CHRM4ESR1ESR2GABRA1GABRB1GABRG2GBA1HRH1HTR1DHTR2AOPRD1OPRK1OPRM1SLC6A2SLC6A3TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8rplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Azaperone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A known ✓ | P28223 | 10/20 | 0.86 |
| ▸ | ADRA2C known ✓ | P18825 | 2/20 | 0.67 |
| ▸ | HRH1 known ✓ | P35367 | 2/20 | 0.67 |
| ▸ | DRD4 | P21917 | 13/20 | 0.86 |
| ▸ | DRD2 | P14416 | 13/20 | 0.86 |
| ▸ | DRD3 | P35462 | 12/20 | 0.86 |
| ▸ | HTR1A | P08908 | 11/20 | 0.86 |
| ▸ | HTR7 | P34969 | 9/20 | 0.86 |
| ▸ | HTR2C | P28335 | 8/20 | 0.86 |
| ▸ | SIGMAR1 | Q99720 | 8/20 | 0.86 |
| ▸ | TMEM97 | Q5BJF2 | 6/20 | 0.86 |
| ▸ | LMNA | P02545 | 1/20 | 0.86 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.86 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.86 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.86 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.86 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.86 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.86 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.60 |
| ▸ | DRD1 | P21728 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Azaperone SCHEMBL29437229 | 0.93 | DRD4 (1.00) | DRD4DRD2DRD3HTR1AHTR2A | |
| Azaperone SCHEMBL121134 | 0.93 | DRD4 (1.00) | DRD4DRD2DRD3HTR1AHTR2A | |
| SCHEMBL6358772 | 0.86 | DRD4 (0.87) | DRD4DRD2DRD3HTR1AHTR2A | |
| SCHEMBL12436913 | 0.82 | DRD4 (0.79) | DRD4DRD2DRD3HTR1AHTR2A | |
| SCHEMBL9631347 | 0.82 | HTR1A (0.79) | DRD4DRD2DRD3HTR1AHTR2A | |
| SCHEMBL28925988 | 0.80 | DRD2 (0.76) | DRD4DRD2DRD3HTR1AHTR2A | |
| SCHEMBL6353873 | 0.79 | DRD4 (0.74) | DRD4DRD2DRD3HTR1AHTR2A | |
| SCHEMBL6351416 | 0.79 | HTR1A (1.00) | DRD4DRD2DRD3HTR1AHTR2A | |
| SCHEMBL11829798 | 0.78 | DRD2 (0.66) | DRD4DRD2DRD3HTR1AHTR2A | |
| SCHEMBL6358178 | 0.78 | DRD4 (1.00) | DRD4DRD2DRD3HTR1AHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9339498-B2 | Sedating and immobilizing non-domesticated mammals | WILDLIFE LABORATORIES, INC. (US) | 2016-05-17 | — | — | US | claimed |
| US-20150290186-A1 | Sedating and Immobilizing Non-Domesticated Mammals | WILDLIFE LABORATORIES, INCORPORATED (US) | 2015-10-15 | — | — | US | claimed |
| US-7795263-B2 | Pharmaceutical combination for and method of anesthetizing and immobilizing non-domesticated mammals | WILDLIFE LABORATORIES, INC. (US) | 2010-09-14 | — | — | US | claimed |
| US-20100010006-A1 | Pharmaceutical Combination for and Method of Anesthetizing and Immobilizing Non-Domesticated Mammals | WILDLIFE LABORATORIES, LLC | 2010-01-14 | — | — | US | claimed |
| US-9339498-B2 | Sedating and immobilizing non-domesticated mammals | WILDLIFE LABORATORIES, INC. (US) | 2016-05-17 | — | — | US | disclosed |
| US-9339498-B2 | Sedating and immobilizing non-domesticated mammals | WILDLIFE LABORATORIES, INC. (US) | 2016-05-17 | — | — | US | disclosed |
| US-20150290186-A1 | Sedating and Immobilizing Non-Domesticated Mammals | WILDLIFE LABORATORIES, INCORPORATED (US) | 2015-10-15 | — | — | US | disclosed |
| US-20150290186-A1 | Sedating and Immobilizing Non-Domesticated Mammals | WILDLIFE LABORATORIES, INCORPORATED (US) | 2015-10-15 | — | — | US | disclosed |
| US-7795263-B2 | Pharmaceutical combination for and method of anesthetizing and immobilizing non-domesticated mammals | WILDLIFE LABORATORIES, INC. (US) | 2010-09-14 | — | — | US | disclosed |
| US-7795263-B2 | Pharmaceutical combination for and method of anesthetizing and immobilizing non-domesticated mammals | WILDLIFE LABORATORIES, INC. (US) | 2010-09-14 | — | — | US | disclosed |
| US-20100010006-A1 | Pharmaceutical Combination for and Method of Anesthetizing and Immobilizing Non-Domesticated Mammals | WILDLIFE LABORATORIES, LLC | 2010-01-14 | — | — | US | disclosed |
| US-20100010006-A1 | Pharmaceutical Combination for and Method of Anesthetizing and Immobilizing Non-Domesticated Mammals | WILDLIFE LABORATORIES, LLC | 2010-01-14 | — | — | US | disclosed |