Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1322804 | 0.87 | HTR1D (0.52) | HTR1DHTR1B | |
| SCHEMBL7479250 | 0.79 | HTR1D (0.84) | HTR1DHTR1B | |
| SCHEMBL13955054 | 0.73 | HTR7 (0.54) | HTR1DHTR1B | |
| SCHEMBL12123966 | 0.71 | HTR1D (0.60) | HTR1DHTR1B | |
| SCHEMBL12123764 | 0.71 | HTR1A (0.50) | HTR1DHTR1B | |
| SCHEMBL7474856 | 0.70 | HTR1D (0.68) | HTR1DHTR1B | |
| SCHEMBL12124025 | 0.70 | HTR7 (0.42) | HTR1DHTR1B | |
| SCHEMBL13955200 | 0.70 | SLC6A4 (0.57) | HTR1D | |
| SCHEMBL1324283 | 0.69 | GRIN2B (0.58) | HTR1DHTR1B | |
| SCHEMBL4579325 | 0.69 | HTR1D (1.00) | HTR1DHTR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8058277-B2 | Substituted indoles | MERCK PATENT GMBH (DE) | 2011-11-15 | — | — | US | disclosed |
| US-20090291963-A1 | SUBSTITUTED INDOLES | SCHADT OLIVER | 2009-11-26 | — | — | US | disclosed |
| US-7572796-B2 | Substituted indoles | MERCK PATENT GMBH (DE) | 2009-08-11 | — | — | US | disclosed |
| US-20090054459-A1 | Substituted indoles | SCHADT OLIVER | 2009-02-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090054459-A1 | Substituted indoles | TPH2, TPH1, HTR1A | HTR1D 13/4885HTR1B 14/4885 |
| US-20090291963-A1 | SUBSTITUTED INDOLES | TPH2, TPH1, HTR1A | HTR1D 11/4885HTR1B 12/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.