Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 1/20 | 0.61 |
| ▸ | HTR2A | P28223 | 1/20 | 0.61 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.61 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.61 |
| ▸ | HTR1A | P08908 | 4/20 | 0.59 |
| ▸ | HTR7 | P34969 | 4/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12124495 | 0.89 | HTR2A (0.61) | SLC6A2HTR2ASLC6A4SLC6A3HTR1A | |
| SCHEMBL15958316 | 0.87 | HTR1A (0.59) | SLC6A2HTR2ASLC6A4SLC6A3HTR1A | |
| SCHEMBL16216950 | 0.86 | SLC6A2 (0.82) | SLC6A2HTR2ASLC6A4SLC6A3HTR1A | |
| SCHEMBL12124635 | 0.85 | SLC6A2 (0.72) | SLC6A2HTR2ASLC6A4SLC6A3HTR1A | |
| SCHEMBL12124499 | 0.82 | SLC6A2 (0.84) | SLC6A2HTR2ASLC6A4SLC6A3HTR1A | |
| SCHEMBL12124704 | 0.82 | HTR1A (0.82) | HTR1AHTR7 | |
| SCHEMBL12124497 | 0.82 | SLC6A2 (0.70) | SLC6A2HTR2ASLC6A4SLC6A3HTR1A | |
| SCHEMBL12124494 | 0.77 | SLC6A2 (0.72) | SLC6A2HTR2ASLC6A4SLC6A3HTR1A | |
| SCHEMBL13367653 | 0.77 | SIGMAR1 (0.65) | — | |
| SCHEMBL12124503 | 0.77 | SLC6A2 (0.72) | SLC6A2HTR2ASLC6A4SLC6A3HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140315919-A1 | HIGHLY SELECTIVE SIGMA RECEPTOR LIGANDS | UNIV MISSISSIPPI (US) | 2014-10-23 | — | — | US | disclosed |
| US-20110280804-A1 | HIGHLY SELECTIVE SIGMA RECEPTOR RADIOLIGANDS | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2011-11-17 | — | — | US | disclosed |
| US-20110195955-A1 | HIGHLY SELECTIVE SIGMA RECEPTOR LIGANDS | L'UNIVERSITE CATHOLIQUE DE LOUVAIN (BE) | 2011-08-11 | — | — | US | disclosed |
| US-20100329978-A1 | HIGHLY SELECTIVE SIGMA RECEPTOR LIGANDS | UNIVERSITY OF MISSISSIPPI (US) | 2010-12-30 | — | — | US | disclosed |
| US-20100329978-A1 | HIGHLY SELECTIVE SIGMA RECEPTOR LIGANDS | UNIVERSITY OF MISSISSIPPI (US) | 2010-12-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100329978-A1 | HIGHLY SELECTIVE SIGMA RECEPTOR LIGANDS | SIGMAR1, OPRL1, CNR1 | SLC6A2 244/4885HTR2A 138/4885SLC6A4 184/4885 |
| US-20140315919-A1 | HIGHLY SELECTIVE SIGMA RECEPTOR LIGANDS | SIGMAR1, OPRD1, OPRM1 | SLC6A2 241/4885HTR2A 45/4885SLC6A4 215/4885 |
| US-20110195955-A1 | HIGHLY SELECTIVE SIGMA RECEPTOR LIGANDS | SIGMAR1, OPRD1, OPRM1 | SLC6A2 241/4885HTR2A 45/4885SLC6A4 215/4885 |
| US-20110280804-A1 | HIGHLY SELECTIVE SIGMA RECEPTOR RADIOLIGANDS | SIGMAR1, MSR1, TMEM97 | SLC6A2 193/4885HTR2A 149/4885SLC6A4 90/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.