Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | GCG | P01275 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.39 |
| ▸ | F10 | P00742 | 4/20 | 0.39 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12136828 | 0.83 | RAB9A (0.46) | RXFP1NPSR1HDAC1NPC1RAB9A | |
| SCHEMBL12136829 | 0.83 | MEN1 (0.48) | NPC1RAB9AGCGMEN1KMT2A | |
| SCHEMBL12136748 | 0.79 | RAB9A (0.59) | RXFP1KDM4ENPSR1NPC1RAB9A | |
| SCHEMBL14372263 | 0.77 | MEN1 (0.50) | RXFP1NPSR1NPC1RAB9APOLB | |
| SCHEMBL12136827 | 0.74 | MAPT (0.47) | RXFP1KDM4EMEN1KMT2AMAPT | |
| SCHEMBL14082233 | 0.73 | KDM4E (0.70) | RXFP1KDM4ENPSR1NPC1RAB9A | |
| SCHEMBL14082429 | 0.71 | RXFP1 (0.60) | RXFP1KDM4ENPSR1NPC1RAB9A | |
| SCHEMBL14083020 | 0.70 | SMN1; SMN2 (0.51) | RXFP1KDM4ENPSR1NPC1RAB9A | |
| SCHEMBL14082683 | 0.69 | RXFP1 (0.56) | RXFP1KDM4ENPSR1HDAC1NPC1 | |
| SCHEMBL14075262 | 0.67 | SMN1; SMN2 (0.62) | KDM4ENPSR1NPC1RAB9AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8067608-B2 | Hedgehog pathway antagonists | THE JOHNS HOPKINS UNIVERSITY (US) | 2011-11-29 | — | — | US | disclosed |
| US-8067608-B2 | Hedgehog pathway antagonists | THE JOHNS HOPKINS UNIVERSITY (US) | 2011-11-29 | — | — | US | disclosed |
| US-20070232661-A1 | Hedgehog Pathway Antagonists | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2007-10-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070232661-A1 | Hedgehog Pathway Antagonists | GLI1, SHH, SMO | RXFP1 2462/4885KDM4E 892/4885NPSR1 4097/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.