Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 5/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | SCN2A | Q99250 | 2/20 | 0.46 |
| ▸ | SCN10A | Q9Y5Y9 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.46 |
| ▸ | RELA | Q04206 | 1/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.44 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.44 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12136827 | 0.87 | MAPT (0.47) | MEN1KMT2ARXFP1MAPTKCNK3 | |
| SCHEMBL12136828 | 0.84 | RAB9A (0.46) | MEN1KMT2ASMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL12136829 | 0.82 | MEN1 (0.48) | MEN1KMT2ASMN1; SMN2LMNANPC1 | |
| SCHEMBL12136826 | 0.77 | RXFP1 (0.50) | MEN1KMT2ANPC1TP53RAB9A | |
| SCHEMBL16495590 | 0.77 | MEN1 (0.70) | MEN1KMT2ASMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL5934348 | 0.72 | SMN1; SMN2 (0.53) | MEN1KMT2ASMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL14083010 | 0.71 | NPC1 (0.52) | KMT2ASMN1; SMN2ALDH1A1SCN2ASCN10A | |
| SCHEMBL5934465 | 0.70 | ROCK2 (0.58) | KMT2ASMN1; SMN2ALDH1A1NPC1TP53 | |
| SCHEMBL10090678 | 0.70 | KMT2A (0.72) | MEN1KMT2ASMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL14083014 | 0.70 | RAB9A (0.55) | MEN1KMT2ASMN1; SMN2ALDH1A1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070232661-A1 | Hedgehog Pathway Antagonists | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2007-10-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070232661-A1 | Hedgehog Pathway Antagonists | GLI1, SHH, SMO | MEN1 2398/4885KMT2A 944/4885SMN1; SMN2 2484/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.