Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | FOLH1 | Q04609 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | KDM6B | O15054 | 1/20 | 0.42 |
| ▸ | KDM5C | P41229 | 1/20 | 0.42 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.42 |
| ▸ | PHF8 | Q9UPP1 | 1/20 | 0.42 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.42 |
| ▸ | ECE1 | P42892 | 1/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.38 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.38 |
| ▸ | TET2 | Q6N021 | 5/20 | 0.37 |
| ▸ | TET3 | O43151 | 1/20 | 0.37 |
| ▸ | TET1 | Q8NFU7 | 1/20 | 0.37 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1809603 | 0.78 | ALOX15 (0.57) | ALOX15HSD17B10TET2TET3TET1 | |
| SCHEMBL3895585 | 0.76 | ALOX15 (0.44) | ALOX15HSD17B10KDM4EKDM5CEGLN1 | |
| SCHEMBL2605603 | 0.76 | ALOX15 (0.44) | ALOX15HSD17B10ECE1HDAC8HDAC6 | |
| SCHEMBL11345101 | 0.74 | ALOX15 (0.43) | ALOX15HSD17B10TET2TET3TET1 | |
| SCHEMBL822245 | 0.73 | — | — | |
| Itaconate SCHEMBL29886131 | 0.73 | — | — | |
| Itaconate SCHEMBL21523 | 0.73 | — | — | |
| Itaconate SCHEMBL286967 | 0.73 | ALOX15 (0.75) | ALOX15HSD17B10KDM4EEGLN1TET2 | |
| SCHEMBL5177523 | 0.72 | MCL1 (0.41) | ALOX15HSD17B10KDM4ETET2TET3 | |
| Malonodihydroxamic Acid SCHEMBL3246123 | 0.71 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2389342-B1 | SURFACE-MODIFIED ZIRCONIA NANOPARTICLES | 3M INNOVATIVE PROPERTIES CO (US) | 2020-11-04 | — | — | EP | disclosed |
| US-8829079-B2 | Surface-modified zirconia nanoparticles | 3M INNOVATIVE PROPERTIES COMPANY (US) | 2014-09-09 | — | — | US | disclosed |
| US-8829079-B2 | Surface-modified zirconia nanoparticles | 3M INNOVATIVE PROPERTIES COMPANY (US) | 2014-09-09 | — | — | US | disclosed |
| US-20110288215-A1 | SURFACE-MODIFIED ZIRCONIA NANOPARTICLES | 3M INNOVATIVE PROPERTIES COMPANY | 2011-11-24 | — | — | US | disclosed |
| US-20110288215-A1 | SURFACE-MODIFIED ZIRCONIA NANOPARTICLES | 3M INNOVATIVE PROPERTIES COMPANY | 2011-11-24 | — | — | US | disclosed |
| WO-2010085427-A1 | SURFACE-MODIFIED ZIRCONIA NANOPARTICLES | 3M INNOVATIVE PROPERTIES COMPANY (US) | 2010-07-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110288215-A1 | SURFACE-MODIFIED ZIRCONIA NANOPARTICLES | ZKSCAN2, CD63, HDAC9 | ALOX15 3256/4885HSD17B10 3455/4885FOLH1 1908/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.