Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Biotin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.90 |
| ▸ | MEN1 | O00255 | 1/20 | 0.90 |
| ▸ | ABL1 | P00519 | 1/20 | 0.90 |
| ▸ | LMNA | P02545 | 1/20 | 0.90 |
| ▸ | PKM | P14618 | 1/20 | 0.90 |
| ▸ | IDE | P14735 | 1/20 | 0.90 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.90 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.90 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.90 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.90 |
| ▸ | HLCS | P50747 | 6/20 | 0.63 |
| ▸ | CA12 | O43570 | 8/20 | 0.57 |
| ▸ | CA1 | P00915 | 8/20 | 0.57 |
| ▸ | CA2 | P00918 | 8/20 | 0.57 |
| ▸ | CA9 | Q16790 | 8/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Biotin SCHEMBL28780778 | 1.00 | TDP1 (0.90) | TDP1MEN1ABL1LMNAPKM | |
| Biotin SCHEMBL4433162 | 0.99 | TDP1 (0.87) | TDP1MEN1ABL1LMNAPKM | |
| Biotin SCHEMBL6648954 | 0.95 | TDP1 (0.85) | TDP1MEN1ABL1LMNAPKM | |
| Biotin SCHEMBL410686 | 0.95 | TDP1 (1.00) | TDP1MEN1ABL1LMNAPKM | |
| Biotin SCHEMBL20547409 | 0.95 | TDP1 (1.00) | TDP1MEN1ABL1LMNAPKM | |
| Biotin SCHEMBL23055065 | 0.95 | TDP1 (1.00) | TDP1MEN1ABL1LMNAPKM | |
| Biotin SCHEMBL21981206 | 0.95 | TDP1 (1.00) | TDP1MEN1ABL1LMNAPKM | |
| Biotin SCHEMBL22943835 | 0.95 | TDP1 (1.00) | TDP1MEN1ABL1LMNAPKM | |
| Biotin SCHEMBL36572 | 0.95 | TDP1 (1.00) | TDP1MEN1ABL1LMNAPKM | |
| Biotin SCHEMBL59420 | 0.95 | TDP1 (1.00) | TDP1MEN1ABL1LMNAPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2193468-B1 | HIGH-RESOLUTION 3D IMAGING OF SINGLE SEMICONDUCTOR NANOCRYSTALS | MASSACHUSETTS INST TECHNOLOGY (US) | 2019-03-27 | — | — | EP | disclosed |
| US-8947516-B2 | High-resolution 3D imaging of single semiconductor nanocrystals | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2015-02-03 | — | — | US | disclosed |
| US-8367377-B2 | Methods and devices for nucleic acid sequence determination | HELICOS BIOSCIENCES CORPORATION (US) | 2013-02-05 | — | — | US | disclosed |
| EP-1766090-B1 | METHODS FOR NUCLEIC ACID IMMOBILISATION | HELICOS BIOSCIENCES CORP (US) | 2011-04-27 | — | — | EP | disclosed |
| US-20110037846-A1 | HIGH-RESOLUTION 3D IMAGING OF SINGLE SEMICONDUCTOR NANOCRYSTALS | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 2011-02-17 | — | — | US | disclosed |
| US-20100227321-A1 | METHODS AND DEVICES FOR NUCLEIC ACID SEQUENCE DETERMINATION | HELICOS BIOSCIENCES CORPORATION (US) | 2010-09-09 | — | — | US | disclosed |
| EP-2193468-A2 | HIGH-RESOLUTION 3D IMAGING OF SINGLE SEMICONDUCTOR NANOCRYSTALS | Massachusetts Institute of Technology (US) | 2010-06-09 | — | — | EP | disclosed |
| US-7635562-B2 | Methods and devices for nucleic acid sequence determination | HELICOS BIOSCIENCES CORPORATION (US) | 2009-12-22 | — | — | US | disclosed |
| WO-2009082523-A2 | HIGH-RESOLUTION 3D IMAGING OF SINGLE SEMICONDUCTOR NANOCRYSTALS | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2009-07-02 | — | — | WO | disclosed |
| EP-1766090-A2 | METHODS AND DEVICES FOR NUCLEIC ACID SEQUENCE DETERMINATION | Helicos Biosciences Corporation (US) | 2007-03-28 | — | — | EP | disclosed |
| US-20060019276-A1 | Methods and devices for nucleic acid sequence determination | FLUIDIGM CORPORATION | 2006-01-26 | — | — | US | disclosed |
| WO-2006007207-A2 | METHODS AND DEVICES FOR NUCLEIC ACID SEQUENCE DETERMINATION | HELICOS BIOSCIENCES CORPORATION (US) | 2006-01-19 | — | — | WO | disclosed |