Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Biotin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.87 |
| ▸ | MEN1 | O00255 | 1/20 | 0.87 |
| ▸ | ABL1 | P00519 | 1/20 | 0.87 |
| ▸ | LMNA | P02545 | 1/20 | 0.87 |
| ▸ | PKM | P14618 | 1/20 | 0.87 |
| ▸ | IDE | P14735 | 1/20 | 0.87 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.87 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.87 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.87 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.87 |
| ▸ | HLCS | P50747 | 6/20 | 0.61 |
| ▸ | CA12 | O43570 | 8/20 | 0.56 |
| ▸ | CA1 | P00915 | 8/20 | 0.56 |
| ▸ | CA2 | P00918 | 8/20 | 0.56 |
| ▸ | CA9 | Q16790 | 8/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Biotin SCHEMBL1215022 | 0.99 | TDP1 (0.90) | TDP1MEN1ABL1LMNAPKM | |
| Biotin SCHEMBL28780778 | 0.99 | TDP1 (0.90) | TDP1MEN1ABL1LMNAPKM | |
| Biotin SCHEMBL398483 | 0.95 | TDP1 (0.97) | TDP1MEN1ABL1LMNAPKM | |
| Biotin SCHEMBL3473268 | 0.95 | TDP1 (0.97) | TDP1MEN1ABL1LMNAPKM | |
| Biotin SCHEMBL6648954 | 0.94 | TDP1 (0.85) | TDP1MEN1ABL1LMNAPKM | |
| Biotin SCHEMBL23055065 | 0.93 | TDP1 (1.00) | TDP1MEN1ABL1LMNAPKM | |
| Biotin SCHEMBL22943835 | 0.93 | TDP1 (1.00) | TDP1MEN1ABL1LMNAPKM | |
| Biotin SCHEMBL36572 | 0.93 | TDP1 (1.00) | TDP1MEN1ABL1LMNAPKM | |
| Biotin SCHEMBL21981206 | 0.93 | TDP1 (1.00) | TDP1MEN1ABL1LMNAPKM | |
| Biotin SCHEMBL20547409 | 0.93 | TDP1 (1.00) | TDP1MEN1ABL1LMNAPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240058293-A1 | Nutritional Formulas Comprising Medium Chain Fatty Acids or Esters Thereof and Methods Related Thereto | UNIV EMORY (US) | 2024-02-22 | — | — | US | disclosed |
| US-11826336-B2 | Nutritional formulas comprising medium chain fatty acids or esters thereof and methods related thereto | EMORY UNIVERSITY (US) | 2023-11-28 | — | — | US | disclosed |
| US-20210283090-A1 | Nutritional Formulas Comprising Medium Chain Fatty Acids or Esters Thereof and Methods Related Thereto | UNIV EMORY (US) | 2021-09-16 | — | — | US | disclosed |
| US-11026913-B2 | Nutritional formulas comprising medium chain fatty acids or esters thereof and methods related thereto | EMORY UNIVERSITY (US) | 2021-06-08 | — | — | US | disclosed |
| US-10765653-B2 | Fatty acid formulations and methods of use thereof | CHILDREN'S HOSPITAL & RESEARCH CENTER OAKLAND (US) | 2020-09-08 | — | — | US | disclosed |
| US-20190328696-A1 | FATTY ACID FORMULATIONS AND METHODS OF USE THEREOF | CHILDREN'S HOSPITAL & RESEARCH CENTER OAKLAND | 2019-10-31 | — | — | US | disclosed |
| EP-3539560-A1 | FATTY ACID FORMULATIONS AND METHODS OF USE THEREOF | Children's Hospital & Research Center at Oakland (US) | 2019-09-18 | — | — | EP | disclosed |
| US-10398671-B2 | Fatty acid formulations and methods of use thereof | CHILDREN'S HOSPITAL & RESEARCH CENTER AT OAKLAND (US) | 2019-09-03 | — | — | US | disclosed |
| US-10300034-B2 | Fatty acid formulations and methods of use thereof | CHILDREN'S HOSPITAL OF OAKLAND RESEARCH INSTITUTE (US) | 2019-05-28 | — | — | US | disclosed |
| EP-2131679-B1 | FATTY ACID FORMULATIONS AND METHODS OF USE THEREOF | CHILDRENS HOSPITAL & RES CENTER AT OAKLAND (US) | 2019-03-27 | — | — | EP | disclosed |
| US-9687016-B2 | Fatty acid formulations and methods of use thereof | CHILDREN'S HOSPITAL & RESEARCH CENTER OAKLAND (US) | 2017-06-27 | — | — | US | disclosed |
| US-20170143655-A1 | FATTY ACID FORMULATIONS AND METHODS OF USE THEREOF | CHILDREN'S HOSPITAL & RESEARCH CENTER AT OAKLAND | 2017-05-25 | — | — | US | disclosed |
| US-20160199337-A1 | Nutritional Formulas Comprising Medium Chain Fatty Acids or Esters Thereof and Methods Related Thereto | CHILDREN'S HEALTHCARE OF ATLANTA, INC. (US) | 2016-07-14 | — | — | US | disclosed |
| WO-2015034984-A1 | NUTRITIONAL FORMULAS COMPRISING MEDIUM CHAIN FATTY ACIDS OR ESTERS THEREOF AND METHODS RELATED THERETO | EMORY UNIVERSITY (US) | 2015-03-12 | — | — | WO | disclosed |
| US-20120190737-A1 | Fatty Acid Formulations and Methods of Use Thereof | CHILDREN'S HOSPITAL & RESEARCH CENTER OAKLAND | 2012-07-26 | — | — | US | disclosed |
| EP-2131679-A1 | FATTY ACID FORMULATIONS AND METHODS OF USE THEREOF | Children's Hospital & Research Center at Oakland (US) | 2009-12-16 | — | — | EP | disclosed |
| US-20080213239-A1 | Dietary mixture comprising docosohexaenoic acid, alpha -tocopherol, gamma tocopherol and eicosapentaenoic acid for use in treatment and prevention of inflammatory, rheumatic and cardiovascular disorders | CHILDREN'S HOSPITAL OF OAKLAND RESEARCH INSTITUTE | 2008-09-04 | — | — | US | disclosed |
| WO-2008103370-A1 | FATTY ACID FORMULATIONS AND METHODS OF USE THEREOF | CHILDREN'S HOSPITAL AND RESEARCH CENTER AT OAKLAND (US) | 2008-08-28 | — | — | WO | disclosed |