Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.66 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.66 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.66 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.66 |
| ▸ | MEN1 | O00255 | 6/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.65 |
| ▸ | LMNA | P02545 | 6/20 | 0.63 |
| ▸ | GAA | P10253 | 3/20 | 0.63 |
| ▸ | HTT | P42858 | 3/20 | 0.63 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.63 |
| ▸ | HPGD | P15428 | 2/20 | 0.63 |
| ▸ | NPC1 | O15118 | 1/20 | 0.63 |
| ▸ | TSHR | P16473 | 1/20 | 0.63 |
| ▸ | RAB9A | P51151 | 1/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.62 |
| ▸ | TP53 | P04637 | 1/20 | 0.62 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.61 |
| ▸ | PGR | P06401 | 1/20 | 0.60 |
| ▸ | MAPT | P10636 | 5/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6633618 | 0.84 | KMT2A (0.89) | ALDH1A1MAPK1ALOX15MEN1KMT2A | |
| SCHEMBL8626226 | 0.82 | ALDH1A1 (0.78) | TDP1ALDH1A1MAPK1ALOX15HSD17B10 | |
| SCHEMBL2575722 | 0.82 | SMN1; SMN2 (0.91) | ALDH1A1MAPK1ALOX15MEN1KMT2A | |
| SCHEMBL12167789 | 0.79 | ALDH1A1 (0.70) | ALDH1A1MEN1KMT2ALMNAGAA | |
| SCHEMBL12167800 | 0.79 | ALDH1A1 (0.76) | ALDH1A1MEN1KMT2ALMNAL3MBTL1 | |
| SCHEMBL27179735 | 0.76 | MEN1 (0.71) | TDP1ALDH1A1MAPK1ALOX15HSD17B10 | |
| SCHEMBL12776733 | 0.76 | MEN1 (0.59) | ALDH1A1MAPK1ALOX15HSD17B10MEN1 | |
| SCHEMBL4069902 | 0.75 | LMNA (0.79) | ALDH1A1MAPK1ALOX15MEN1KMT2A | |
| SCHEMBL328331 | 0.75 | AKT1 (1.00) | ALDH1A1MEN1KMT2ALMNAHTT | |
| SCHEMBL31605457 | 0.75 | ALDH1A1 (0.80) | TDP1ALDH1A1MAPK1ALOX15HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8268885-B2 | Entry inhibitors of the HIV virus | JANSSEN R&D IRELAND (IE) | 2012-09-18 | — | — | US | disclosed |
| US-8268885-B2 | Entry inhibitors of the HIV virus | JANSSEN R&D IRELAND (IE) | 2012-09-18 | — | — | US | disclosed |
| EP-1667675-B1 | ENTRY INHIBITORS OF THE HIV VIRUS | TIBOTEC PHARM LTD (IE) | 2011-11-09 | — | — | EP | disclosed |
| US-20070066623-A1 | Entry inhibitors of the hiv virus | JANSSEN R&D IRELAND (IE) | 2007-03-22 | — | — | US | disclosed |
| US-20070066623-A1 | Entry inhibitors of the hiv virus | JANSSEN R&D IRELAND (IE) | 2007-03-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070066623-A1 | Entry inhibitors of the hiv virus | HAVCR2, CCR5, SAMHD1 | TDP1 4074/4885ALDH1A1 3208/4885MAPK1 2085/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.