SCHEMBL121701

SCHEMBL121701

CCCC[Si]([NH])(c1ccccc1)c1ccccc1

nearest known ligand 0.41

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
TSHR P16473 2/20 0.36
LTA4H P09960 2/20 0.35
PCSK9 Q8NBP7 1/20 0.35
ESR1 P03372 1/20 0.34
ESR2 Q92731 1/20 0.34
PTGS2 P35354 1/20 0.34
NAAA Q02083 1/20 0.34
AR P10275 1/20 0.34
HTT P42858 2/20 0.33
SMN1; SMN2 Q16637 1/20 0.33
SIGMAR1 Q99720 1/20 0.33
CES2 O00748 1/20 0.33
CES1 P23141 1/20 0.33
HSD11B1 P28845 1/20 0.33
EPHX2 P34913 1/20 0.33
ALDH1A1 P00352 1/20 0.33
EPHX1 P07099 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3886636 0.77 TSHR (0.38) TSHRLTA4HPCSK9PTGS2NAAA
SCHEMBL27604670 0.77 TSHR (0.38) TSHRLTA4HPCSK9PTGS2NAAA
SCHEMBL5801979 0.76 NR1H2 (0.53) TSHRLTA4HPCSK9ESR1ESR2
SCHEMBL2103061 0.75 TDP1 (0.34) TSHRLTA4HPCSK9NAAAHTT
SCHEMBL707815 0.74 DNM1 (0.36) TSHRLTA4HPCSK9PTGS2NAAA
SCHEMBL705289 0.74 TSHR (0.36) TSHRLTA4HPCSK9PTGS2NAAA
SCHEMBL706115 0.74 TSHR (0.36) TSHRLTA4HPCSK9PTGS2NAAA
SCHEMBL706939 0.74 TSHR (0.36) TSHRLTA4HPCSK9PTGS2NAAA
SCHEMBL18108273 0.74 SIGMAR1 (0.37) TSHRLTA4HPCSK9PTGS2NAAA
SCHEMBL121702 0.74 SMN1; SMN2 (0.37) TSHRLTA4HPCSK9PTGS2NAAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2013154774-A1 BLOCK COPOLYMERS FOR STABLE MICELLES INTEZYNE TECHNOLOGIES, INC. (US) 2013-10-17 WO disclosed
EP-2427176-A1 POLYMER MICELLES CONTAINING SN-38 FOR THE TREATMENT OF CANCER Intezyne Technologies Inc. (US) 2012-03-14 EP disclosed
EP-2424359-A1 POLYMER MICELLES CONTAINING ANTHRACYLINES FOR THE TREATMENT OF CANCER Intezyne Technologies Inc. (US) 2012-03-07 EP disclosed
WO-2011088405-A1 PLASMA MODIFICATION OF METAL SURFACES INTEZYNE TECHNOLOGIES, INCORPORATED (US) 2011-07-21 WO disclosed
EP-2283063-A1 SYNTHESIS OF HYBRID BLOCK COPOLYMERS FROM DIFLUOROACETATE AMMONIUM SALTS Intezyne Technologies Inc. (US) 2011-02-16 EP disclosed
WO-2010129581-A1 POLYMER MICELLES CONTAINING SN-38 FOR THE TREATMENT OF CANCER INTEZYNE TECHNOLOGIES, INCORPORATED (US) 2010-11-11 WO disclosed
WO-2010127271-A1 POLYMER MICELLES CONTAINING ANTHRACYLINES FOR THE TREATMENT OF CANCER INTEZYNE TECHNOLOGIES, INCORPORATED (US) 2010-11-04 WO disclosed
EP-2152320-A2 ENCAPSULATED CONTRAST AGENTS Intezyne Technologies Incorporated (US) 2010-02-17 EP disclosed
WO-2009134984-A1 SYNTHESIS OF HYBRID BLOCK COPOLYMERS FROM DIFLUOROACETATE AMMONIUM SALTS INTEZYNE TECHNOLGIES INC. (US) 2009-11-05 WO disclosed
EP-2073850-A1 HYBRID BLOCK COPOLYMER MICELLES WITH MIXED STEREOCHEMISTRY FOR ENCAPSULATION OF HYDROPHOBIC AGENTS Intezyne Technologies Incorporated (US) 2009-07-01 EP disclosed
WO-2008134734-A2 ENCAPSULATED CONTRAST AGENTS INTEZYNE TECHNOLOGIES, INC. (US) 2008-11-06 WO disclosed
WO-2008134731-A1 HYBRID BLOCK COPOLYMER MICELLES WITH MIXED STEREOCHEMISTRY FOR ENCAPSULATION OF HYDROPHOBIC AGENTS INTEZYNE TECHNOLOGIES, INC. (US) 2008-11-06 WO disclosed
WO-2008106657-A2 ENCAPSULATED AMYLOID-BETA PEPTIDES INTEZYNE TECHNOLOGIES, INC. (US) 2008-09-04 WO disclosed
US-5691319-A ANTICARCINOGENIC AGENTS SANKYO COMPANY, LIMITED (JP) 1997-11-25 US disclosed
EP-0536936-B1 Pyrimidine nucleoside derivatives having anti-tumor activity, their preparation and use SANKYO CO (JP) 1996-08-14 EP disclosed
EP-0536936-A1 Pyrimidine nucleoside derivatives having anti-tumor activity, their preparation and use Sankyo Company Limited (JP) 1993-04-14 EP disclosed