SCHEMBL705289

SCHEMBL705289

CCCC[Si](Br)(Br)c1ccccc1

nearest known ligand 0.41

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
TSHR P16473 2/20 0.36
TDP1 Q9NUW8 1/20 0.36
NR1H2 P55055 1/20 0.36
NR1H3 Q13133 1/20 0.36
LTA4H P09960 2/20 0.35
PCSK9 Q8NBP7 1/20 0.35
PTGS2 P35354 1/20 0.34
NAAA Q02083 1/20 0.34
AR P10275 1/20 0.34
SMN1; SMN2 Q16637 1/20 0.33
HTT P42858 1/20 0.33
SIGMAR1 Q99720 1/20 0.33
CES2 O00748 1/20 0.33
CES1 P23141 1/20 0.33
NR1I2 O75469 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18108369 0.92 KCNH2 (0.42) NAAASMN1; SMN2HTTCES2CES1
SCHEMBL18108181 0.92 KCNH2 (0.42) NAAASMN1; SMN2HTTCES2CES1
SCHEMBL706935 0.89 NR1H2 (0.43) NR1H2NR1H3AR
SCHEMBL708300 0.86 TP53 (0.35) TSHRTDP1NR1H2NR1H3
SCHEMBL705811 0.86 ALDH1A1 (0.33) TSHRTDP1
SCHEMBL708106 0.86 ALDH1A1 (0.33) TSHRTDP1
SCHEMBL706939 0.83 TSHR (0.36) TSHRLTA4HPCSK9PTGS2NAAA
SCHEMBL18108273 0.83 SIGMAR1 (0.37) TSHRLTA4HPCSK9PTGS2NAAA
SCHEMBL706954 0.81 ALDH1A1 (0.35) TSHRTDP1
SCHEMBL18108206 0.81 LTA4H (0.38) TSHRNR1H2NR1H3LTA4HPCSK9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9884928-B2 Polymers functionalized with activated nitrogen heterocycles containing a pendant functional group BRIDGESTONE CORPORATION (JP) 2018-02-06 US disclosed
US-20160289354-A1 POLYMERS FUNCTIONALIZED WITH ACTIVATED NITROGEN HETEROCYCLES CONTAINING A PENDANT FUNCTIONAL GROUP BRIDGESTONE CORPORATION (JP) 2016-10-06 US disclosed
EP-2599836-B1 CURABLE COMPOSITION FOR SEMICONDUCTOR ENCAPSULATION ADEKA CORP (JP) 2015-03-25 EP disclosed
US-8470937-B2 Curable composition for semiconductor encapsulation ADEKA CORPORATION (JP) 2013-06-25 US disclosed
EP-2599836-A1 CURABLE COMPOSITION FOR SEMICONDUCTOR ENCAPSULATION Adeka Corporation (JP) 2013-06-05 EP disclosed
US-20120126435-A1 CURABLE COMPOSITION FOR SEMICONDUCTOR ENCAPSULATION ADEKA CORPORATION (JP) 2012-05-24 US disclosed
US-8124239-B2 Silica film forming material, silica film and method of manufacturing the same, multilayer wiring structure and method of manufacturing the same, and semiconductor device and method of manufacturing the same FUJITSU LIMITED (JP) 2012-02-28 US disclosed
US-20100155121-A1 SILICA FILM FORMING MATERIAL, SILICA FILM AND METHOD OF MANUFACTURING THE SAME, MULTILAYER WIRING STRUCTURE AND METHOD OF MANUFACTURING THE SAME, AND SEMICONDUCTOR DEVICE AND METHOD OF MANUFACTURING THE SAME FUJITSU LIMITED (JP) 2010-06-24 US disclosed
US-7659357-B2 Precursor organosilicon polymer of 1,2-Bis(dimethylethoxysilyl)ethane, 1,4-bis(dimethylethoxysilyl)benzene, tetraethoxysilane, methyltriethoxysilane, phenyltriethoxysilane; dielectric (DE) films having etching/chemical/moisture resistance; adhesion; low DE constant; minimal wiring delay; high speed FUJITSU LIMITED (JP) 2010-02-09 US disclosed
US-20070026689-A1 Silica film forming material, silica film and method of manufacturing the same, multilayer wiring structure and method of manufacturing the same, and semiconductor device and method of manufacturing the same FUJITSU LIMITED (JP) 2007-02-01 US disclosed