Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PI4KA | P42356 | 2/20 | 0.42 |
| ▸ | PI4K2B | Q8TCG2 | 2/20 | 0.42 |
| ▸ | PI4K2A | Q9BTU6 | 2/20 | 0.42 |
| ▸ | PI4KB | Q9UBF8 | 2/20 | 0.42 |
| ▸ | ADORA3 | P0DMS8 | 4/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | SLC29A1 | Q99808 | 2/20 | 0.39 |
| ▸ | DPP4 | P27487 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | SLC28A1 | O00337 | 1/20 | 0.39 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.39 |
| ▸ | SLC28A2 | O43868 | 1/20 | 0.39 |
| ▸ | GAPDH | P04406 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.39 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.39 |
| ▸ | STAT6 | P42226 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | DOT1L | Q8TEK3 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15203793 | 1.00 | PI4KA (0.42) | PI4KAPI4K2BPI4K2API4KBADORA3 | |
| SCHEMBL15203798 | 0.87 | ADORA3 (0.54) | PI4KAPI4K2BPI4K2API4KBADORA3 | |
| SCHEMBL15203968 | 0.85 | PI4KA (0.45) | PI4KAPI4K2BPI4K2API4KBADORA3 | |
| SCHEMBL15203967 | 0.85 | PI4KA (0.45) | PI4KAPI4K2BPI4K2API4KBADORA3 | |
| SCHEMBL18947551 | 0.84 | LMNA (0.34) | PI4KAPI4K2BPI4K2API4KBADORA3 | |
| SCHEMBL18948230 | 0.84 | PI4KA (0.41) | PI4KAPI4K2BPI4K2API4KBADORA3 | |
| SCHEMBL15203742 | 0.83 | CYP2C19 (0.43) | ADORA3SLC29A1ADORA2BADORA1AHCY | |
| SCHEMBL15203741 | 0.83 | CYP2C19 (0.43) | ADORA3SLC29A1ADORA2BADORA1AHCY | |
| SCHEMBL18947540 | 0.83 | ADORA2A (0.35) | PI4KAPI4K2BPI4K2API4KBADORA2A | |
| SCHEMBL3659976 | 0.82 | PI4KA (0.41) | PI4KAPI4K2BPI4K2API4KBADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9676808-B2 | 2′,4′-substituted nucleosides as antiviral agents | GILEAD PHARMASSET LLC (US) | 2017-06-13 | — | — | US | disclosed |
| US-20160280735-A1 | 2',4'-SUBSTITUTED NUCLEOSIDES AS ANTIVIRAL AGENTS | GILEAD SCIENCES, INC. | 2016-09-29 | — | — | US | disclosed |
| US-20160280735-A1 | 2',4'-SUBSTITUTED NUCLEOSIDES AS ANTIVIRAL AGENTS | GILEAD SCIENCES, INC. | 2016-09-29 | — | — | US | disclosed |
| EP-2848624-A1 | 2',4'-substituted nucleosides as antiviral agents | Gilead Pharmasset LLC (US) | 2015-03-18 | — | — | EP | disclosed |
| EP-2631239-A1 | 2',4'-substituted nucleosides as antiviral agents | Gilead Pharmasset LLC (US) | 2013-08-28 | — | — | EP | disclosed |
| US-20120232029-A1 | 2',4'-SUBSTITUTED NUCLEOSIDES AS ANTIVIRAL AGENTS | PHARMASSET, INC. (US) | 2012-09-13 | — | — | US | disclosed |
| US-20090318380-A1 | 2',4'-SUBSTITUTED NUCLEOSIDES AS ANTIVIRAL AGENTS | PHARMASSET, INC. (US) | 2009-12-24 | — | — | US | disclosed |
| US-20090318380-A1 | 2',4'-SUBSTITUTED NUCLEOSIDES AS ANTIVIRAL AGENTS | PHARMASSET, INC. (US) | 2009-12-24 | — | — | US | disclosed |
| WO-2009067409-A1 | 2',4'-SUBSTITUTED NUCLEOSIDES AS ANTIVIRAL AGENTS | PHARMASSET, INC. (US) | 2009-05-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090318380-A1 | 2',4'-SUBSTITUTED NUCLEOSIDES AS ANTIVIRAL AGENTS | HAVCR2, NUDT1, NT5C3B | PI4KA 1143/4885PI4K2B 1832/4885PI4K2A 1611/4885 |
| US-20120232029-A1 | 2',4'-SUBSTITUTED NUCLEOSIDES AS ANTIVIRAL AGENTS | HAVCR2, NUDT1, NT5C3B | PI4KA 1143/4885PI4K2B 1832/4885PI4K2A 1611/4885 |
| US-20160280735-A1 | 2',4'-SUBSTITUTED NUCLEOSIDES AS ANTIVIRAL AGENTS | HAVCR2, NUDT1, NT5C3B | PI4KA 1143/4885PI4K2B 1832/4885PI4K2A 1611/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.