Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 6/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | HSD17B1 | P14061 | 3/20 | 0.43 |
| ▸ | HSD17B2 | P37059 | 3/20 | 0.43 |
| ▸ | GPBAR1 | Q8TDU6 | 6/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | CRHBP | P24387 | 1/20 | 0.39 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.39 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.36 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.36 |
| ▸ | PGR | P06401 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23009384 | 0.78 | KMT2A (0.51) | MEN1KMT2AGPBAR1NR1H2NR1H3 | |
| SCHEMBL12173019 | 0.77 | HSD17B1 (0.43) | MEN1KMT2ASMN1; SMN2HSD17B1HSD17B2 | |
| SCHEMBL12173034 | 0.77 | GPBAR1 (0.48) | SMN1; SMN2HSD17B1HSD17B2GPBAR1ALDH1A1 | |
| SCHEMBL9426030 | 0.71 | HDAC6 (0.37) | MEN1KMT2AGPBAR1NR1H2NR1H3 | |
| SCHEMBL12938525 | 0.71 | HSD17B1 (0.57) | KMT2ASMN1; SMN2HSD17B1HSD17B2ALDH1A1 | |
| Toluene SCHEMBL27455697 | 0.71 | MEN1 (0.56) | MEN1KMT2ASMN1; SMN2MAPK1CYP1A2 | |
| SCHEMBL2089214 | 0.70 | ALDH1A1 (0.52) | MEN1KMT2ASMN1; SMN2HSD17B1HSD17B2 | |
| SCHEMBL257815 | 0.70 | KMT2A (0.61) | MEN1KMT2ASMN1; SMN2HSD17B1HSD17B2 | |
| SCHEMBL12173025 | 0.70 | POLB (0.56) | MEN1KMT2AHSD17B1HSD17B2ALDH1A1 | |
| Hydrochloric Acid SCHEMBL11840917 | 0.69 | ALDH1A1 (0.50) | MEN1KMT2ASMN1; SMN2HSD17B1HSD17B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150031663-A1 | PHTHALANILATE COMPOUNDS AND METHODS OF USE | UNIVERSITY OF NOTRE DAME DU LAC (US) | 2015-01-29 | — | — | US | disclosed |
| US-8859620-B2 | Phthalanilate compounds and methods of use | UNIVERSITY OF NOTRE DAME DU LAC (US) | 2014-10-14 | — | — | US | disclosed |
| US-20120232150-A1 | PHTHALANILATE COMPOUNDS AND METHODS OF USE | University of Nortre Dame du Lac | 2012-09-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120232150-A1 | PHTHALANILATE COMPOUNDS AND METHODS OF USE | MPO, ALPI, NQO1 | MEN1 2365/4885KMT2A 1142/4885SMN1; SMN2 4278/4885 |
| US-20150031663-A1 | PHTHALANILATE COMPOUNDS AND METHODS OF USE | MPO, ALPI, NQO1 | MEN1 2365/4885KMT2A 1142/4885SMN1; SMN2 4278/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.