SCHEMBL12176972

SCHEMBL12176972

Nc1nccc(-c2ccc(-c3ccccc3)cc2)n1

nearest known ligand 0.92

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HSP90AA1 P07900 2/20 0.92
ADORA2A P29274 2/20 0.92
AURKA O14965 2/20 0.92
PRKACA P17612 1/20 0.92
HSP90AB1 P08238 1/20 0.62
PTK2 Q05397 1/20 0.62
RAB9A P51151 3/20 0.62
NPC1 O15118 2/20 0.62
KMO O15229 1/20 0.56
KDM4E B2RXH2 4/20 0.56
ALDH1A1 P00352 4/20 0.56
MAPT P10636 2/20 0.56
MAPK13 O15264 1/20 0.55
RAF1 P04049 1/20 0.55
MAPK9 P45984 1/20 0.55
MAPK12 P53778 1/20 0.55
MAPK11 Q15759 1/20 0.55
MAPK14 Q16539 1/20 0.55
ADORA1 P30542 1/20 0.55
SMN1; SMN2 Q16637 2/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL316210 0.96 HSP90AA1 (1.00) HSP90AA1ADORA2AAURKAPRKACAHSP90AB1
Hydrochloric Acid SCHEMBL17186384 0.94 HSP90AA1 (0.96) HSP90AA1ADORA2AAURKAPRKACAHSP90AB1
SCHEMBL4202167 0.87 HSP90AA1 (0.76) HSP90AA1ADORA2AAURKAPRKACAHSP90AB1
SCHEMBL712182 0.86 HSP90AA1 (0.69) HSP90AA1ADORA2AAURKAPRKACAHSP90AB1
SCHEMBL28013042 0.84 HSP90AA1 (0.71) HSP90AA1ADORA2AAURKAPRKACAHSP90AB1
SCHEMBL21164006 0.83 HSP90AA1 (0.70) HSP90AA1ADORA2AAURKAPRKACAHSP90AB1
Trifluoroacetic Acid SCHEMBL28137418 0.81 HSP90AA1 (0.72) HSP90AA1ADORA2AAURKAPRKACAHSP90AB1
SCHEMBL13977475 0.81 HSP90AA1 (0.62) HSP90AA1ADORA2AAURKAPRKACAHSP90AB1
SCHEMBL17200126 0.80 HSP90AA1 (0.66) HSP90AA1ADORA2AAURKAPRKACAHSP90AB1
SCHEMBL3412705 0.80 KMO (0.66) HSP90AA1ADORA2AAURKAPRKACAHSP90AB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2011136483-A1 NOVEL COMPOUNDS FOR ORGANIC ELECTRONIC MATERIAL AND ORGANIC ELECTROLUMINESCENT DEVICE USING THE SAME ROHM AND HAAS ELECTRONIC MATERIALS KOREA LTD. (KR) 2011-11-03 WO disclosed