Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGAM | O43451 | 1/20 | 0.60 |
| ▸ | CA12 | O43570 | 1/20 | 0.60 |
| ▸ | CA1 | P00915 | 1/20 | 0.60 |
| ▸ | CA2 | P00918 | 1/20 | 0.60 |
| ▸ | CA9 | Q16790 | 1/20 | 0.60 |
| ▸ | AURKA | O14965 | 10/20 | 0.58 |
| ▸ | LMNA | P02545 | 2/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.52 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.52 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.49 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.49 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12177755 | 0.97 | AURKA (0.60) | MGAMCA12CA1CA2CA9 | |
| SCHEMBL12177783 | 0.92 | MGAM (0.57) | MGAMCA12CA1CA2CA9 | |
| SCHEMBL12177489 | 0.90 | ALDH1A1 (0.57) | MGAMCA12CA1CA2CA9 | |
| SCHEMBL12177724 | 0.90 | ALDH1A1 (0.59) | MGAMCA12CA1CA2CA9 | |
| SCHEMBL12177727 | 0.90 | ALDH1A1 (0.59) | MGAMCA12CA1CA2CA9 | |
| SCHEMBL12177685 | 0.90 | AURKA (0.65) | MGAMCA12CA1CA2CA9 | |
| SCHEMBL12177288 | 0.89 | TDP1 (0.55) | MGAMCA12CA1CA2CA9 | |
| SCHEMBL12177509 | 0.87 | CA9 (0.61) | MGAMCA12CA1CA2CA9 | |
| SCHEMBL12177166 | 0.86 | AURKA (0.70) | MGAMCA12CA1CA2CA9 | |
| SCHEMBL12177688 | 0.85 | CA9 (0.57) | MGAMCA12CA1CA2CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011135303-A2 | UBIQUITINATION MODULATORS | ITI SCOTLAND LIMITED (GB) | 2011-11-03 | — | — | WO | disclosed |