Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.53 |
| ▸ | ACHE | P22303 | 1/20 | 0.48 |
| ▸ | MEP1B | Q16820 | 1/20 | 0.48 |
| ▸ | ALPL | P05186 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14520037 | 0.86 | KMT2A (0.57) | ACHEKMT2AUSP2GAASMN1; SMN2 | |
| SCHEMBL20364526 | 0.81 | GAA (0.49) | ACHEKMT2AUSP2GAAMAPK1 | |
| SCHEMBL12888826 | 0.79 | MCOLN3 (0.57) | MCOLN3ACHEMEP1BALPLKMT2A | |
| SCHEMBL28325511 | 0.78 | MCOLN3 (0.49) | MCOLN3ACHEMEP1BALPLKMT2A | |
| SCHEMBL16360367 | 0.78 | TP53 (0.47) | ALPLKMT2ASMN1; SMN2MAPK1LMNA | |
| SCHEMBL13290903 | 0.78 | MCOLN3 (0.55) | MCOLN3ACHEMEP1BALPLKMT2A | |
| SCHEMBL6367227 | 0.78 | MCOLN3 (0.55) | MCOLN3ACHEMEP1BALPLKMT2A | |
| SCHEMBL51171 | 0.78 | MCOLN3 (0.55) | MCOLN3ACHEMEP1BALPLKMT2A | |
| SCHEMBL533956 | 0.78 | TRPV4 (0.68) | MCOLN3ACHEMEP1BALPLKMT2A | |
| SCHEMBL29469916 | 0.78 | MCOLN3 (0.55) | MCOLN3ACHEMEP1BALPLKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11912736-B2 | Diaryl trehalose compounds and uses thereof | THE UNIVERSITY OF MONTANA (US) | 2024-02-27 | — | — | US | disclosed |
| WO-2019165114-A1 | DIARYL TREHALOSE COMPOUNDS AND USES THEREOF | THE UNIVERSITY OF MONTANA (US) | 2019-08-29 | — | — | WO | disclosed |
| US-9365588-B2 | Benzoxazines as modulators of ion channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2016-06-14 | — | — | US | disclosed |
| US-20140309220-A1 | BENZOXAZINES AS MODULATORS OF ION CHANNELS | VERTEX PHARMACEUTICALS INCORPORATED | 2014-10-16 | — | — | US | disclosed |
| US-20140171427-A1 | Heterocyclic chromene-spirocyclic piperidine amides as modulators of ion channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2014-06-19 | — | — | US | disclosed |
| WO-2013067248-A1 | BENZOXAZINES AS MODULATORS OF ION CHANNELS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2013-05-10 | — | — | WO | disclosed |
| US-20110306607-A1 | HETEROCYCLIC CHROMENE-SPIROCYCLIC PIPERIDINE AMIDES AS MODULATORS OF ION CHANNELS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2011-12-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140171427-A1 | Heterocyclic chromene-spirocyclic piperidine amides as modulators of ion channels | KCNJ2, TRPV1, KCNJ1 | MCOLN3 2233/4885ACHE 725/4885MEP1B 1899/4885 |
| US-20110306607-A1 | HETEROCYCLIC CHROMENE-SPIROCYCLIC PIPERIDINE AMIDES AS MODULATORS OF ION CHANNELS | KCNJ2, TRPV1, KCNJ1 | MCOLN3 2233/4885ACHE 725/4885MEP1B 1899/4885 |
| US-20140309220-A1 | BENZOXAZINES AS MODULATORS OF ION CHANNELS | KCNJ1, KCNJ2, KCNJ11 | MCOLN3 514/4885ACHE 520/4885MEP1B 1971/4885 |
| US-11912736-B2 | Diaryl trehalose compounds and uses thereof | TREH, STT3B, DDOST | MCOLN3 1186/4885ACHE 616/4885MEP1B 2855/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.