Sugi Predict

Sugi Predict / Compounds / SCHEMBL533956

SCHEMBL533956

SCHEMBL533956

COc1cc(C)ccc1S(=O)(=O)Cl

nearest known ligand 0.68

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ TRPV4 Q9HBA0 1/20 0.68
▸ MCOLN3 Q8TDD5 1/20 0.55
▸ ACHE P22303 1/20 0.52
▸ MEP1B Q16820 1/20 0.50
▸ ALPL P05186 2/20 0.48
▸ KMT2A Q03164 3/20 0.47
▸ GAA P10253 2/20 0.47
▸ USP2 O75604 1/20 0.47
▸ MAPK1 P28482 2/20 0.47
▸ SMN1; SMN2 Q16637 2/20 0.45
▸ LMNA P02545 1/20 0.45
▸ PKM P14618 1/20 0.45
▸ HTT P42858 1/20 0.45
▸ MEN1 O00255 2/20 0.44
▸ L3MBTL1 Q9Y468 1/20 0.44
▸ TSHR P16473 1/20 0.44
▸ ALDH1A1 P00352 3/20 0.44
▸ POLB P06746 1/20 0.44
▸ CA1 P00915 1/20 0.43
▸ CA2 P00918 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL739940 0.85 KMT2A (0.60) TRPV4ACHEKMT2AGAAUSP2
SCHEMBL12888826 0.82 MCOLN3 (0.57) TRPV4MCOLN3ACHEMEP1BALPL
SCHEMBL29482639 0.81 TRPV4 (0.68) TRPV4ALPLGAAL3MBTL1ALDH1A1
SCHEMBL2947794 0.81 TRPV4 (1.00) TRPV4ALPLKMT2AGAAMAPK1
SCHEMBL29469916 0.81 MCOLN3 (0.55) TRPV4MCOLN3ACHEMEP1BALPL
SCHEMBL13290903 0.81 MCOLN3 (0.55) TRPV4MCOLN3ACHEMEP1BALPL
SCHEMBL51171 0.81 MCOLN3 (0.55) TRPV4MCOLN3ACHEMEP1BALPL
SCHEMBL6367227 0.81 MCOLN3 (0.55) TRPV4MCOLN3ACHEMEP1BALPL
SCHEMBL74997 0.81 TRPV4 (0.68) TRPV4ALPLGAAL3MBTL1ALDH1A1
SCHEMBL29420268 0.81 TRPV4 (1.00) TRPV4ALPLKMT2AGAAMAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 185 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1377589-B1 OXAZOLYL-PYRAZOLE DERIVATIVES AS KINASE INHIBITORS PHARMACIA ITALIA SPA (IT) 2005-09-07 — — EP claimed
US-6211223-B1 BENZODIOXOL-5-YL-2-METHOXY-4-METHYLPHENYLSULFONYLAMINO-2-OXO ETHYL-1-METHYL-1HINDOLE-6-CARBOXYLIC ACID PFIZER INC. 2001-04-03 — — US claimed
WO-1999020623-A1 INDOLE DERIVATIVE USEFUL AS ENDOTHELIN RECEPTOR ANTAGONIST PFIZER LIMITED (GB) 1999-04-29 — — WO claimed
US-12509462-B2 3-(phenylsulfonyl)-[1,2,3]triazolo[1,5A]quinazolin-5(4H)-one derivatives BioVersys AG (CH) 2025-12-30 — — US disclosed
US-20250145637-A1 SULFONAMIDE DERIVATIVE, PREPARATION METHOD THEREFOR AND MEDICAL USE THEREOF JIANGSU HENGRUI PHARMACEUTICALS CO., LTD. (CN) 2025-05-08 — — US disclosed
CN-113195493-B 3- (Benzenesulfonyl) - [1,2,3] triazolo [1,5a ] quinazolin-5 (4H) -one derivatives 生物验证系统股份公司 2025-05-02 — — CN disclosed
EP-3887375-B1 3-(PHENYLSULFONYL)-[1,2,3]TRIAZOLO[1,5A]QUINAZOLIN-5(4H)-ONE DERIVATIVES BioVersys AG (CH) 2024-11-20 — — EP disclosed
EP-4385989-A1 SULFONAMIDE DERIVATIVE, PREPARATION METHOD THEREFOR AND MEDICAL USE THEREOF Jiangsu Hengrui Pharmaceuticals Co., Ltd. (CN) 2024-06-19 — — EP disclosed
CN-117597341-A Sulfonamide derivative, preparation method and application thereof in medicine 江苏恒瑞医药股份有限公司 2024-02-23 — — CN disclosed
WO-2023016484-A1 SULFONAMIDE DERIVATIVE, PREPARATION METHOD THEREFOR AND MEDICAL USE THEREOF 江苏恒瑞医药股份有限公司 2023-02-16 — — WO disclosed
WO-2023016484-A1 SULFONAMIDE DERIVATIVE, PREPARATION METHOD THEREFOR AND MEDICAL USE THEREOF 江苏恒瑞医药股份有限公司 2023-02-16 — — WO disclosed
US-20030149029-A1 Methods for treating asthmatic conditions WYETH 2003-08-07 — — US disclosed
US-20030149020-A1 New compounds PROXIMAGEN NEUROSCIENCE PLC (GB) 2003-08-07 — — US disclosed
US-20030144282-A1 Inhibitors of cytosolic phospholipase A2 WYETH 2003-07-31 — — US disclosed
EP-1283831-A1 INHIBITORS OF 11-BETA-HYDROXY STEROID DEHYDROGENASE TYPE 1 BIOVITRUM AB (SE) 2003-02-19 — — EP disclosed
WO-2002100822-A1 SUBSTITUTED SULFONAMIDE COMPOUNDS, PROCESS FOR THEIR USE AS MEDICAMENT FOR THE TREATMENT OF CNS DISORDERS, OBESITY AND TYPE II DIABETES BIOVITRUM AB (SE) 2002-12-19 — — WO disclosed
WO-2002092585-A1 NOVEL, ARYLSUSFONAMIDE COMPOUNDS FOR THE TREATMENT OF OBESITY, TYPE II DIABETES AND CNS-DISORDERS BIOVITRUM AB (SE) 2002-11-21 — — WO disclosed
WO-2001090090-A1 INHIBITORS OF 11-BETA-HYDROXY STEROID DEHYDROGENASE TYPE 1 BIOVITRUM AB (SE) 2001-11-29 — — WO disclosed
US-6211223-B1 BENZODIOXOL-5-YL-2-METHOXY-4-METHYLPHENYLSULFONYLAMINO-2-OXO ETHYL-1-METHYL-1HINDOLE-6-CARBOXYLIC ACID PFIZER INC. 2001-04-03 — — US disclosed
WO-1999020623-A1 INDOLE DERIVATIVE USEFUL AS ENDOTHELIN RECEPTOR ANTAGONIST PFIZER LIMITED (GB) 1999-04-29 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030149020-A1 New compounds GPR119, SULT2A1, NAT1 TRPV4 1585/4885MCOLN3 3315/4885ACHE 1666/4885
US-20250145637-A1 SULFONAMIDE DERIVATIVE, PREPARATION METHOD THEREFOR AND MEDICAL USE THEREOF SULT2A1, KAT8, TST TRPV4 4216/4885MCOLN3 3291/4885ACHE 1094/4885
US-12509462-B2 3-(phenylsulfonyl)-[1,2,3]triazolo[1,5A]quinazolin-5(4H)-one derivatives CUTA, OR10J3, CCR10 TRPV4 2399/4885MCOLN3 1130/4885ACHE 1751/4885
US-20030149029-A1 Methods for treating asthmatic conditions PLA2G4A, PLA2G4B, PLA2G1B TRPV4 338/4885MCOLN3 1438/4885ACHE 123/4885
US-20030144282-A1 Inhibitors of cytosolic phospholipase A2 PLA2G4A, PLA2G4B, PLA2G4C TRPV4 205/4885MCOLN3 1774/4885ACHE 398/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.