Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | ACACB | O00763 | 2/20 | 0.45 |
| ▸ | ALDH1A3 | P47895 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.43 |
| ▸ | KDM4A | O75164 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.41 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6196209 | 0.83 | POLB (0.55) | POLBGAACYP1A2CYP2D6CYP2C19 | |
| SCHEMBL24630912 | 0.81 | SLC6A4 (0.64) | CYP1A2CYP2D6CYP2C19SLC6A4 | |
| SCHEMBL13072262 | 0.81 | SLC6A4 (0.64) | CYP1A2CYP2D6CYP2C19SLC6A4 | |
| SCHEMBL12313578 | 0.79 | SLC6A4 (0.68) | SLC6A4 | |
| SCHEMBL14449300 | 0.78 | POLB (0.59) | POLBGAACYP1A2CYP2D6CYP2C19 | |
| SCHEMBL13003657 | 0.78 | POLB (0.50) | POLBGAACYP1A2CYP2D6CYP2C19 | |
| SCHEMBL24973088 | 0.78 | NQO1 (0.56) | ACACB | |
| SCHEMBL125543 | 0.76 | ALDH1A3 (0.64) | POLBGAACYP1A2CYP2D6CYP2C19 | |
| SCHEMBL10508149 | 0.76 | POLB (0.49) | POLBGAACYP1A2CYP2D6CYP2C19 | |
| SCHEMBL16383175 | 0.76 | SLC6A4 (0.69) | CYP1A2CYP2D6CYP2C19SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8034364-B2 | Implantable medical device comprising a pro-healing(ester-amide) | ADVANCED CARDIOVASCULAR SYSTEMS, INC. (US) | 2011-10-11 | — | — | US | disclosed |
| US-8030436-B2 | Poly(ester-amide) elastomers and their use with implantable medical devices | ADVANCED CARDIOVASCULAR SYSTEMS, INC. (US) | 2011-10-04 | — | — | US | disclosed |
| US-20100217379-A1 | IMPLANTABLE MEDICAL DEVICE COMPRISING A PRO-HEALING POLY(ESTER-AMIDE) | ADVANCED CARDIOVASCULAR SYSTEMS, INC. | 2010-08-26 | — | — | US | disclosed |
| US-7731987-B2 | everolimus drug reservoir layer comprising PEA-TEMPO (a poly(ester-amide) to which 2,2,6,6-tetramethyl-4-aminopiperidineoxyl has been covalently appended); PEA-TEMPO has very desirable in vivo properties, it is quite permeable to everolimus; sustained release; stent; for drug delivery | ADVANCED CARDIOVASCULAR SYSTEMS, INC. (US) | 2010-06-08 | — | — | US | disclosed |
| US-20090181063-A1 | IMPLANTABLE MEDICAL DEVICE COMPRISING A PRO-HEALING POLY(ESTER-AMIDE) | ABBOTT CARDIOVASCULAR SYSTEMS INC. | 2009-07-16 | — | — | US | disclosed |
| US-20080014245-A1 | Drug-eluting implantable medical device with free radical scavenger for protecting drugs during sterilization and related method | ADVANCED CARDIOVASCULAR SYSTEMS, INC. | 2008-01-17 | — | — | US | disclosed |
| US-20080014241-A1 | everolimus drug reservoir layer comprising PEA-TEMPO (a poly(ester-amide) to which 2,2,6,6-tetramethyl-4-aminopiperidineoxyl has been covalently appended); PEA-TEMPO has very desirable in vivo properties, it is quite permeable to everolimus; sustained release; stent; for drug delivery | ADVANCED CARDIOVASCULAR SYSTEMS, INC. | 2008-01-17 | — | — | US | disclosed |
| US-20080014236-A1 | Poly(ester-amide) elastomers and their use with implantable medical devices | ADVANCED CARDIOVASCULAR SYSTEMS, INC. | 2008-01-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100217379-A1 | IMPLANTABLE MEDICAL DEVICE COMPRISING A PRO-HEALING POLY(ESTER-AMIDE) | PAM, PUF60, ATF4 | POLB 3125/4885GAA 1874/4885CYP1A2 2189/4885 |
| US-20090181063-A1 | IMPLANTABLE MEDICAL DEVICE COMPRISING A PRO-HEALING POLY(ESTER-AMIDE) | PAM, PUF60, ATF4 | POLB 3125/4885GAA 1874/4885CYP1A2 2189/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.