Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 5/20 | 0.57 |
| ▸ | PRKCZ | Q05513 | 13/20 | 0.56 |
| ▸ | IKBKB | O14920 | 2/20 | 0.53 |
| ▸ | CHUK | O15111 | 1/20 | 0.44 |
| ▸ | LCK | P06239 | 1/20 | 0.44 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2500632 | 0.83 | PRKCZ (0.61) | PRKCZIKBKBROCK1 | |
| SCHEMBL2505022 | 0.78 | PRKCZ (0.54) | PRKCZIKBKBCHUKROCK1 | |
| SCHEMBL12192931 | 0.77 | PRKCZ (0.65) | PRKCZIKBKBCHUKROCK1 | |
| SCHEMBL12192805 | 0.77 | PRKCZ (0.65) | PRKCZIKBKBROCK1 | |
| Hydrochloric Acid SCHEMBL2502330 | 0.76 | PRKCZ (0.63) | PRKCZIKBKBCHUKROCK1 | |
| SCHEMBL24437475 | 0.74 | HRH1 (1.00) | HRH1 | |
| SCHEMBL2505961 | 0.73 | HRH1 (0.52) | HRH1IKBKBCHUKLCKROCK1 | |
| SCHEMBL17981095 | 0.72 | PRKCZ (0.62) | PRKCZIKBKBCHUKLCKROCK1 | |
| SCHEMBL11063126 | 0.71 | IKBKB (0.68) | HRH1PRKCZIKBKBROCK1 | |
| SCHEMBL12192867 | 0.71 | IKBKB (0.91) | HRH1PRKCZIKBKBCHUKLCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8722671-B2 | Isoquinoline derivatives | SANOFI (FR) | 2014-05-13 | — | — | US | disclosed |
| US-8722671-B2 | Isoquinoline derivatives | SANOFI (FR) | 2014-05-13 | — | — | US | disclosed |
| US-8501736-B2 | Isoquinoline derivatives | SANOFI (FR) | 2013-08-06 | — | — | US | disclosed |
| US-8501736-B2 | Isoquinoline derivatives | SANOFI (FR) | 2013-08-06 | — | — | US | disclosed |
| US-20110245248-A1 | ISOQUINOLINE DERIVATIVES | SANOFI-AVENTIS (FR) | 2011-10-06 | — | — | US | disclosed |
| US-20110245248-A1 | ISOQUINOLINE DERIVATIVES | SANOFI-AVENTIS (FR) | 2011-10-06 | — | — | US | disclosed |
| US-20090088429-A1 | Isoquinoline Derivatives | SANOFI-AVENTIS (FR) | 2009-04-02 | — | — | US | disclosed |
| US-20090088429-A1 | Isoquinoline Derivatives | SANOFI-AVENTIS (FR) | 2009-04-02 | — | — | US | disclosed |
| WO-2007000240-A1 | ISOQUINOLINE DERIVATIVES AS INHIBITORS OF RHO-KINASE | SANOFI-AVENTIS (DE) | 2007-01-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110245248-A1 | ISOQUINOLINE DERIVATIVES | MYLK2, MYLK, RHOT2 | HRH1 2904/4885PRKCZ 74/4885IKBKB 866/4885 |
| US-20090088429-A1 | Isoquinoline Derivatives | MYLK2, MYLK, RHOT2 | HRH1 2904/4885PRKCZ 74/4885IKBKB 866/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.