Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 1/20 | 0.51 |
| ▸ | PNMT | P11086 | 4/20 | 0.48 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.48 |
| ▸ | TDP2 | O95551 | 1/20 | 0.46 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.45 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.42 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.42 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | CAPN9 | O14815 | 1/20 | 0.39 |
| ▸ | CASP3 | P42574 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL379349 | 0.83 | TDP2 (0.48) | CRBNPNMTADRA2ATDP2AKR1B1 | |
| SCHEMBL12199728 | 0.77 | TSHR (0.42) | CRBNAKR1B1GRIN2BTDP1MEN1 | |
| SCHEMBL16659357 | 0.77 | TSHR (0.42) | CRBNPNMTADRA2ATDP2AKR1B1 | |
| SCHEMBL12199729 | 0.75 | TSHR (0.57) | CRBNAKR1B1TDP1MAPT | |
| SCHEMBL9483063 | 0.75 | PNMT (0.65) | PNMTADRA2ATDP2ADRA2BADRA2C | |
| SCHEMBL30709850 | 0.75 | PNMT (0.65) | PNMTADRA2ATDP2ADRA2BADRA2C | |
| SCHEMBL2061978 | 0.74 | PNMT (0.53) | PNMTADRA2ATDP2ADRA2BADRA2C | |
| SCHEMBL16659358 | 0.73 | ALDH1A1 (0.53) | CRBNTDP2TDP1MEN1MAPT | |
| SCHEMBL16659373 | 0.72 | CRBN (0.45) | CRBNTDP1MAPTRAB9A | |
| SCHEMBL21484128 | 0.72 | CRBN (0.67) | CRBNMEN1LMNAMAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9296750-B2 | Spirolactam CGRP receptor antagonists | MERCK SHARP & DOHME CORP. (US) | 2016-03-29 | — | — | US | disclosed |
| US-20150111914-A1 | SPIROLACTAM CGRP RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME LLC | 2015-04-23 | — | — | US | disclosed |
| US-20110245240-A1 | CGRP RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME CORP. | 2011-10-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110245240-A1 | CGRP RECEPTOR ANTAGONISTS | CCKAR, CALCRL, QRFPR | CRBN 3154/4885PNMT 2414/4885ADRA2A 54/4885 |
| US-20150111914-A1 | SPIROLACTAM CGRP RECEPTOR ANTAGONISTS | CALCRL, CALCR, TACR1 | CRBN 3488/4885PNMT 2396/4885ADRA2A 213/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.