SCHEMBL12200636

SCHEMBL12200636

COc1ccc(C(NC(=O)OCC2c3ccccc3-c3ccccc32)c2ccc(OCC(=O)CNC(c3ccc(C)cc3)c3ccc(C)cc3)cc2)c(OC)c1

nearest known ligand 0.43

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
▸ KMT2A Q03164 5/20 0.43
▸ MEN1 O00255 3/20 0.43
▸ MDM2 Q00987 2/20 0.38
▸ ADAMTS5 Q9UNA0 1/20 0.38
▸ NPC1 O15118 1/20 0.36
▸ RAB9A P51151 1/20 0.36
▸ POLB P06746 1/20 0.36
▸ CASP3 P42574 1/20 0.35
▸ KDM4E B2RXH2 1/20 0.35
▸ ALDH1A1 P00352 1/20 0.35
▸ THRA P10827 1/20 0.35
▸ THRB P10828 1/20 0.35
▸ TP53 P04637 1/20 0.35
▸ SMN1; SMN2 Q16637 1/20 0.35
▸ FABP5 Q01469 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13227693 0.98 KMT2A (0.45) KMT2AMEN1MDM2ADAMTS5NPC1
SCHEMBL13379273 0.91 KMT2A (0.42) KMT2AMEN1MDM2ADAMTS5NPC1
SCHEMBL14450381 0.90 KMT2A (0.46) KMT2AMEN1MDM2ADAMTS5NPC1
SCHEMBL14007040 0.90 KMT2A (0.51) KMT2AMEN1MDM2ADAMTS5NPC1
SCHEMBL29368397 0.89 KMT2A (0.45) KMT2AMEN1MDM2NPC1RAB9A
SCHEMBL29470540 0.89 KMT2A (0.45) KMT2AMEN1MDM2NPC1RAB9A
SCHEMBL1745934 0.89 KMT2A (0.45) KMT2AMEN1MDM2NPC1RAB9A
SCHEMBL31146900 0.89 KMT2A (0.45) KMT2AMEN1MDM2NPC1RAB9A
SCHEMBL3367289 0.89 KMT2A (0.45) KMT2AMEN1MDM2NPC1RAB9A
SCHEMBL1000962 0.89 KMT2A (0.45) KMT2AMEN1MDM2NPC1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230190864-A1 PURIFIED AMPHIPHILIC PEPTIDE COMPOSITIONS AND USES THEREOF 3-D MATRIX, LTD. (JP) 2023-06-22 — — US disclosed
US-9919065-B2 Somatostatin analogs with inhibitory activity to growth hormone release THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2018-03-20 — — US disclosed
US-20160317607-A1 Purified Amphiphilic Peptide Compositions and Uses Thereof 3-D MATRIX, LTD. (JP) 2016-11-03 — — US disclosed
US-20160213793-A1 SOMATOSTATIN ANALOGS WITH INHIBITORY ACTIVITY TO GROWTH HORMONE RELEASE THE REGENTS OF THE UNIVERSITY OF CALIFORNIA 2016-07-28 — — US disclosed
US-9200054-B2 Somatostatin analogs with inhibitory activity to growth hormone release THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2015-12-01 — — US disclosed
US-20140179598-A1 SOMATOSTATIN ANALOGS WITH INHIBITORY ACTIVITY TO GROWTH HORMONE RELEASE THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2014-06-26 — — US disclosed
US-20130281547-A1 Purified Amphiphilic Peptide Compositions and Uses Thereof 3D MATRIX, INC. 2013-10-24 — — US disclosed
US-8562948-B2 Somatostatin analogs with inhibitory activity to growth hormone release THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2013-10-22 — — US disclosed
US-20110243845-A1 SOMATOSTATIN ANALOGS WITH INHIBITORY ACTIVITY TO GROWTH HORMONE RELEASE THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2011-10-06 — — US disclosed
US-7968080-B2 Somatostatin analogs with inhibitory activity to growth hormone release THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2011-06-28 — — US disclosed
US-20070041902-A1 Somatostatin analogs with inhibitory activity to growth hormone release NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2007-02-22 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160213793-A1 SOMATOSTATIN ANALOGS WITH INHIBITORY ACTIVITY TO GROWTH HORMONE RELEASE GHRHR, GHSR, SSTR4 KMT2A 4611/4885MEN1 117/4885MDM2 1958/4885
US-20070041902-A1 Somatostatin analogs with inhibitory activity to growth hormone release GHRHR, GHSR, SSTR4 KMT2A 4611/4885MEN1 117/4885MDM2 1958/4885
US-20230190864-A1 PURIFIED AMPHIPHILIC PEPTIDE COMPOSITIONS AND USES THEREOF IAPP, NGLY1, VIP KMT2A 4520/4885MEN1 935/4885MDM2 276/4885
US-20140179598-A1 SOMATOSTATIN ANALOGS WITH INHIBITORY ACTIVITY TO GROWTH HORMONE RELEASE GHRHR, GHSR, SSTR4 KMT2A 4611/4885MEN1 117/4885MDM2 1958/4885
US-20110243845-A1 SOMATOSTATIN ANALOGS WITH INHIBITORY ACTIVITY TO GROWTH HORMONE RELEASE GHRHR, GHSR, SSTR4 KMT2A 4611/4885MEN1 117/4885MDM2 1958/4885
US-20160317607-A1 Purified Amphiphilic Peptide Compositions and Uses Thereof IAPP, NGLY1, VIP KMT2A 4520/4885MEN1 935/4885MDM2 276/4885
US-20130281547-A1 Purified Amphiphilic Peptide Compositions and Uses Thereof IAPP, NGLY1, VIP KMT2A 4520/4885MEN1 935/4885MDM2 276/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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