Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 4/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | PKM | P14618 | 1/20 | 0.52 |
| ▸ | STS | P08842 | 1/20 | 0.48 |
| ▸ | GPR119 | Q8TDV5 | 8/20 | 0.46 |
| ▸ | BRD4 | O60885 | 1/20 | 0.45 |
| ▸ | RORC | P51449 | 1/20 | 0.44 |
| ▸ | FPR3 | P25089 | 1/20 | 0.44 |
| ▸ | FPR2 | P25090 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5548685 | 0.79 | ABL1 (0.48) | STSMAPT | |
| Hydrochloric Acid SCHEMBL1856109 | 0.76 | TGFBR1 (0.57) | TGFBR1KDM4EPKMSTSGPR119 | |
| SCHEMBL7803789 | 0.76 | KDM4E (0.69) | TGFBR1KDM4EPKMSTSGPR119 | |
| SCHEMBL12205201 | 0.75 | TGFBR1 (0.56) | TGFBR1KDM4EPKMSTSGPR119 | |
| SCHEMBL5547776 | 0.75 | RXFP1 (0.45) | — | |
| SCHEMBL31071538 | 0.75 | TGFBR1 (0.51) | TGFBR1KDM4EPKMSTSGPR119 | |
| SCHEMBL18280017 | 0.75 | TGFBR1 (0.53) | TGFBR1KDM4EPKMSTSGPR119 | |
| SCHEMBL3087666 | 0.75 | KDM4E (0.70) | TGFBR1KDM4EPKMSTSGPR119 | |
| SCHEMBL25301261 | 0.74 | TGFBR1 (0.76) | TGFBR1KDM4EPKMSTSMAPT | |
| SCHEMBL1443815 | 0.74 | KDM4E (0.54) | TGFBR1KDM4EPKMSTSBRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1780211-A2 | Vanilloid receptor ligands and their use in treatments | Amgen Inc. (US) | 2007-05-02 | — | — | EP | disclosed |
| EP-1775295-A1 | Vanilloid receptor ligands and their use in treatments | Amgen Inc. (US) | 2007-04-18 | — | — | EP | disclosed |