Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | NOS1 | P29475 | 1/20 | 0.33 |
| ▸ | NOS2 | P35228 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | ERN1 | O75460 | 1/20 | 0.33 |
| ▸ | HSD17B14 | Q9BPX1 | 1/20 | 0.33 |
| ▸ | GRM5 | P41594 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | POLQ | O75417 | 1/20 | 0.31 |
| ▸ | CES1 | P23141 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9183270 | 0.80 | ALDH1A1 (0.44) | ALDH1A1KDM4EMAPK1RAB9AMAPT | |
| SCHEMBL2861141 | 0.78 | CYP2D6 (0.42) | ALDH1A1KDM4ENOS1NOS2RAB9A | |
| SCHEMBL13338160 | 0.76 | CYP2D6 (0.41) | ALDH1A1KDM4EMAPK1RAB9AMAPT | |
| SCHEMBL19415152 | 0.73 | POLQ (0.35) | ALDH1A1KDM4EMAPTNPSR1CYP2D6 | |
| SCHEMBL5374860 | 0.73 | NTRK1 (0.42) | ALDH1A1MAPK1MAPT | |
| SCHEMBL28446737 | 0.72 | KDM4E (0.47) | ALDH1A1KDM4ERAB9AMAPTTP53 | |
| SCHEMBL8802907 | 0.69 | CYP2D6 (0.33) | ALDH1A1KDM4ERAB9AMAPTNPSR1 | |
| SCHEMBL2702055 | 0.67 | ALDH1A1 (0.43) | ALDH1A1KDM4ENOS1NOS2RAB9A | |
| SCHEMBL890760 | 0.67 | NOS3 (0.35) | ALDH1A1KDM4ENOS1NOS2RAB9A | |
| SCHEMBL2093675 | 0.64 | CES2 (0.34) | ALDH1A1RAB9AERN1CES1NFE2L2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8039632-B2 | 2-aminio-pyridine derivatives and their use as potassium channel modulators | NEUROSEARCH A/S (DK) | 2011-10-18 | — | — | US | disclosed |
| US-8039632-B2 | 2-aminio-pyridine derivatives and their use as potassium channel modulators | NEUROSEARCH A/S (DK) | 2011-10-18 | — | — | US | disclosed |
| US-20100056584-A1 | NOVEL 2-AMINIO-PYRIDINE DERIVATIVES AND THEIR USE AS POTASSIUM CHANNEL MODULATORS | NEUROSEARCH A/S (DK) | 2010-03-04 | — | — | US | disclosed |
| US-20100056584-A1 | NOVEL 2-AMINIO-PYRIDINE DERIVATIVES AND THEIR USE AS POTASSIUM CHANNEL MODULATORS | NEUROSEARCH A/S (DK) | 2010-03-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100056584-A1 | NOVEL 2-AMINIO-PYRIDINE DERIVATIVES AND THEIR USE AS POTASSIUM CHANNEL MODULATORS | KCNN2, KCNN1, KCNN3 | ALDH1A1 4016/4885KDM4E 393/4885NOS1 3232/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.