Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.81 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.81 |
| ▸ | LMNA | P02545 | 2/20 | 0.76 |
| ▸ | PKM | P14618 | 1/20 | 0.76 |
| ▸ | MAPT | P10636 | 3/20 | 0.65 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.62 |
| ▸ | POLB | P06746 | 2/20 | 0.62 |
| ▸ | CA1 | P00915 | 7/20 | 0.62 |
| ▸ | CA2 | P00918 | 7/20 | 0.62 |
| ▸ | CA12 | O43570 | 5/20 | 0.62 |
| ▸ | CA9 | Q16790 | 4/20 | 0.62 |
| ▸ | THRB | P10828 | 1/20 | 0.60 |
| ▸ | CA4 | P22748 | 1/20 | 0.57 |
| ▸ | CA5A | P35218 | 1/20 | 0.57 |
| ▸ | CA7 | P43166 | 1/20 | 0.57 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12224808 | 0.88 | MEN1 (0.63) | MEN1KMT2ALMNAPKMMAPT | |
| SCHEMBL24355560 | 0.87 | MEN1 (0.81) | MEN1KMT2ALMNAMAPTMAPK1 | |
| SCHEMBL10143991 | 0.80 | MAPT (0.66) | MEN1KMT2ALMNAPKMMAPT | |
| SCHEMBL2562498 | 0.79 | MAPT (0.58) | MEN1KMT2ALMNAPKMMAPT | |
| SCHEMBL11887691 | 0.78 | LMNA (0.69) | MEN1KMT2ALMNAMAPTMAPK1 | |
| SCHEMBL21729896 | 0.78 | RAB9A (0.67) | MEN1KMT2AMAPTMAPK1SMN1; SMN2 | |
| SCHEMBL7794429 | 0.78 | CA1 (0.69) | MEN1KMT2AMAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL15579508 | 0.78 | POLB (0.77) | MEN1KMT2ALMNAMAPTMAPK1 | |
| SCHEMBL13263684 | 0.76 | CA1 (1.00) | MEN1KMT2ALMNAMAPTCA1 | |
| SCHEMBL4302252 | 0.76 | KMT2A (0.64) | MEN1KMT2AMAPTMAPK1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8673913-B2 | SHP-2 phosphatase inhibitor | CASE WESTERN RESERVE UNIVERSITY (US) | 2014-03-18 | — | — | US | disclosed |
| US-8673913-B2 | SHP-2 phosphatase inhibitor | CASE WESTERN RESERVE UNIVERSITY (US) | 2014-03-18 | — | — | US | disclosed |
| US-20110257184-A1 | SHP-2 PHOSPHATASE INHIBITOR | CASE WESTERN RESERVE UNIVERSITY | 2011-10-20 | — | — | US | disclosed |
| US-20110257184-A1 | SHP-2 PHOSPHATASE INHIBITOR | CASE WESTERN RESERVE UNIVERSITY | 2011-10-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110257184-A1 | SHP-2 PHOSPHATASE INHIBITOR | PTPN2, PTPRJ, SHPRH | MEN1 3073/4885KMT2A 1528/4885LMNA 4738/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.